Abstract
Thirty patients with idiopathic Parkinson's disease were treated with deep brain stimulation electrode in the subthalamic nucleus. After surgery, the patients' best mean Unified Parkinson's Disease Rating Scale (UPDRS III) scores (medictionOFF-stimulatorON versus preoperative medicationOFF) were 77+/-14% at 3 months ( n=20 patients) and 72+/-14% at 12 months follow-up ( n=16). The mean reduction in therapy (expressed in levodopa dose equivalents in mg) was 68+/-25% at 12 months. Postoperative complications were rare, mostly mild, and reversible. Therapeutic success depends on a multidisciplinary team approach, meticulous patient selection, including patients' cognitive, psychic, and behavioral status, and patient and family lifestyles.
Citations
Jan 5, 2013·Journal of Neurology·Jens VolkmannWolfgang Oertel
Dec 31, 2009·Biological cybernetics·George L TsirogiannisKonstantina S Nikita
Apr 24, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sara MarcegliaUNKNOWN DBS Study Group of The Italian Neurological Society
Jan 1, 2008·Neuromodulation : Journal of the International Neuromodulation Society·Yasin TemelVeerle Visser-Vandewalle
Dec 20, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·R R GoodmanG M McKhann
Dec 31, 2005·Journal of Neurosurgery·Frances WeaverMatthew Stern
Oct 16, 2010·Acta neurochirurgica·Lo J BourP Richard Schuurman
Jul 27, 2010·Acta neurochirurgica·Efstathios J BoviatsisDamianos E Sakas
Aug 16, 2011·Neuropsychology Review·Gottfried SchlaugCatherine Y Wan
Feb 17, 2005·Australasian Physical & Engineering Sciences in Medicine·M Shoushtarian, B Lithgow
Jan 18, 2008·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Sara MarcegliaSergio Cerutti
Aug 11, 2011·PloS One·María Jesús NicolásJulio Artieda
May 3, 2006·Biological Psychiatry·Mark Jeremy HuntRene Garcia
Dec 29, 2009·Experimental Neurology·Manuela RosaAlberto Priori
Mar 15, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Bernadette C M van WijkVladimir Litvak
Mar 15, 2006·Brain Research Bulletin·G FoffaniA Priori
Oct 1, 2010·Neurosurgery·Helen Brontë-StewartJaimie M Henderson
Feb 5, 2011·Stereotactic and Functional Neurosurgery·Paresh K Doshi
Jul 1, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Valerie VoonAlexander I Tröster
Jul 1, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Günther DeuschlValerie Voon
Aug 8, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Galit Kleiner-FismanGünther Deuschl
Jul 12, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Alice PoissonStéphane Thobois
Nov 10, 2010·Brain : a Journal of Neurology·Maria C Rodriguez-OrozJose A Obeso
May 28, 2005·Neurosurgery·Clement HamaniAndres M Lozano