Deep brain stimulation for psychiatric diseases: what are the risks?

Current Psychiatry Reports
Christian Saleh, Denys Fontaine

Abstract

Despite the application of deep brain stimulation (DBS) as an efficient treatment modality for psychiatric disorders, such as obsessive-compulsive disorder (OCD), Gilles de la Tourette Syndrome (GTS), and treatment refractory major depression (TRD), few patients are operated or included in clinical trials, often for fear of the potential risks of an approach deemed too dangerous. To assess the surgical risks, we conducted an analysis of publications on DBS for psychiatric disorders. A PubMed search was conducted on reports on DBS for OCD, GTS, and TRD. Forty-nine articles were included. Only reports on complications related to DBS were selected and analyzed. Two hundred seventy-two patients with a mean follow-up of 22 months were included in our analysis. Surgical mortality was nil. The overall mortality was 1.1 %: two suicides were unrelated to DBS and one death was reported to be unlikely due to DBS. The majority of complications were transient and related to stimulation. Long-term morbidity occurred in 16.5 % of cases. Three patients had permanent neurological complications due to intracerebral hemorrhage (2.2 %). Complications reported in DBS for psychiatric diseases appear to be similar to those reported for DBS in movemen...Continue Reading

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Citations

Jan 20, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Anouk Y J M SmeetsLinda Ackermans
Apr 4, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Dirk De RidderSven Vanneste
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Oct 24, 2020·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Keyoumars AshkanLuciano Furlanetti

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