Deep brain stimulation for treatment-resistant major depressive disorder: a comparison of two targets and long-term follow-up

Translational Psychiatry
S RaymaekersBart Nuttin

Abstract

We previously found that electrical stimulation in the anterior limb of the internal capsule/bed nucleus of the stria terminalis (IC/BST) alleviates depressive symptoms in severe treatment-resistant obsessive-compulsive disorder (OCD) patients. Here we tested the hypothesis that electrical stimulation in either IC/BST or in the inferior thalamic peduncle (ITP) effectively reduces depressive symptoms in treatment-resistant major depressive disorder (TRD). In a double-blind crossover design, the effects of electrical stimulation at both targets were compared in TRD patients. The 17-item Hamilton Depression Rating scale (HAM-D) was the primary outcome measure. During the first crossover, patients received IC/BST stimulation versus no stimulation in random order (2 × 1 weeks). During the second crossover (3 × 2 months), patients received IC/BST versus ITP versus no stimulation. Patients and evaluators were blinded for stimulation conditions. All patients (n=7) were followed up for at least 3 years (3-8 years) after implantation. Six patients completed the first crossover and five patients completed the second. During the first crossover, mean (s.d.) HAM-D scores were 21.5 (2.7) for no stimulation and 11.5 (8.8) for IC/BST stimulati...Continue Reading

References

Feb 19, 1999·Psychosomatic Medicine·L R WulsinV E Wells
Feb 15, 2000·The American Journal of Psychiatry·D A SolomonJ Endicott
May 24, 2003·Neurosurgery·Bart J NuttinHilde G Demeulemeester
Apr 17, 2004·The Journal of ECT·Daniel PagninGiovanni Battista Cassano
Jun 15, 2005·Clinical and Experimental Dermatology·K J Hamill, W H I McLean
Apr 13, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas E SchlaepferVolker Sturm
May 7, 2008·Archives of General Psychiatry·William W EatonPeter Zandi
Jul 22, 2008·Biological Psychiatry·Andres M LozanoSydney H Kennedy
Oct 10, 2008·Biological Psychiatry·Donald A MaloneBenjamin D Greenberg
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael DavisChristian Grillon
Feb 3, 2011·The American Journal of Psychiatry·Sidney H KennedyAndres M Lozano
Jul 23, 2011·The International Journal of Neuropsychopharmacology·Dolors PuigdemontVíctor Pérez
Jan 4, 2012·Archives of General Psychiatry·Paul E HoltzheimerHelen S Mayberg
Jan 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura LuytenBart Nuttin
Apr 5, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bettina H BewernickThomas E Schlaepfer
Mar 27, 2013·Journal of Psychiatry & Neuroscience : JPN·Rajamannar RamasubbuZelma H T Kiss
Apr 9, 2013·Biological Psychiatry·Thomas E SchlaepferVolker A Coenen
Nov 2, 2013·The Journal of Clinical Investigation·Nolan R Williams, Michael S Okun
Apr 1, 2014·Journal of Affective Disorders·Pim CuijpersAnnemieke van Straten

❮ Previous
Next ❯

Citations

Dec 6, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Junus M van der WalDamiaan Denys
Sep 3, 2020·Journal of Clinical Medicine·Frederick L HittiGordon H Baltuch
Aug 28, 2020·Journal of Clinical Medicine·Milaine RoetAli Jahanshahi
Feb 4, 2021·Journal of Neural Transmission·Kerstin SchwabeKai G Kahl
Dec 12, 2020·Frontiers in Human Neuroscience·Benjamin DavidsonClement Hamani
Feb 26, 2021·Der Nervenarzt·Stephan Klebe, Volker Coenen
Mar 25, 2021·Deutsches Ärzteblatt International·Thomas E SchläpferVolker A Coenen
Jul 13, 2021·Frontiers in Human Neuroscience·Mehmet Utku KucukerPaul E Croarkin
Oct 24, 2020·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Keyoumars AshkanLuciano Furlanetti
Aug 19, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M A TumovaM V Ivanov
Sep 2, 2021·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Manoj P DandekarJoao Quevedo

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Related Concepts

Related Feeds

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.