Deep brain stimulation of the centromedian thalamic nucleus for the treatment of FIRES.

Epilepsia Open
Jasmine L HectTaylor J Abel

Abstract

Febrile infection-related epilepsy syndrome (FIRES) is a rare, life-threatening complication of febrile illness in previously healthy individuals followed by super-refractory status epilepticus. Deep brain stimulation (DBS) has been demonstrated to be a promising therapy for the treatment of intractable epilepsy. Here, we present a pediatric patient with FIRES whose seizures were mitigated by acute DBS of the bilateral centromedian thalamic nucleus (CMTN). This is a previously healthy 11-year-old female who presented emergently with altered mental status, fever, and malaise after 1 week of lethargy, anorexia, fever, and abdominal pain. The patient began having seizures shortly after admission. After thorough workup for encephalitis and other potential etiologies, this patient was diagnosed with FIRES due to super-refractory status epilepticus. Status epilepticus persisted despite pharmacologic management, immunotherapy, and vagus nerve stimulation. DBS of the bilateral CMTN (CM-DBS) was pursued after 56 days of hospitalization, and she demonstrated considerable improvement in baseline mental status 30 days after DBS insertion. This report highlights application of CM-DBS for super-refractory status epilepticus in FIRES. This re...Continue Reading

References

Jan 16, 2002·Archives of Neurology·Hal Blumenfeld
Oct 14, 2011·Epilepsia·Matthew C Walker
Aug 18, 2012·Lancet Neurology·Hal Blumenfeld
Apr 8, 2017·Epilepsia·Arthur Cukiert, Kai Lehtimäki
Aug 2, 2018·Neurosurgical Focus·Neil Klinger, Sandeep Mittal
Dec 12, 2018·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Lia D ErnstDavid C Spencer
Dec 14, 2018·Journal of Neurosurgery. Pediatrics·Han YanGeorge M Ibrahim
Mar 5, 2019·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Adeel IlyasSandipan Pati
Jun 28, 2019·Frontiers in Neurology·Nasser ZangiabadiJosé Francisco Téllez-Zenteno
Aug 26, 2019·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Mario SaAntonio Valentin
Jan 26, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Aaron E L WarrenJohn Archer
May 7, 2020·Developmental Medicine and Child Neurology·Nicola Specchio, Nicola Pietrafusa
Aug 30, 2020·Annals of Clinical and Translational Neurology·Churl-Su KwonSaadi Ghatan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Related Papers

SAGE Open Medical Case Reports
Cinthya CarrascoEbtesam Islam
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Alejandra VasquezPediatric Status Epilepticus Research Group (pSERG)
© 2022 Meta ULC. All rights reserved