Deep Brain Stimulation of the internal globus pallidus in refractory Tourette Syndrome

Clinical Neurology and Neurosurgery
A Y J M SmeetsLinda Ackermans

Abstract

Deep Brain Stimulation in psychiatric disorders is becoming an increasingly performed surgery. At present, seven different targets have been stimulated in Tourette Syndrome, including the internal globus pallidus. We describe the effects on tics and comorbid behavioral disorders of Deep Brain Stimulation of the anterior internal globus pallidus in five patients with refractory Tourette Syndrome. This study was performed as an open label study with follow-up assessment between 12 and 38 months. Patients were evaluated twice, one month before surgery and at long-term follow-up. Primary outcome was tic severity, assessed by several scales. Secondary outcomes were comorbid behavioral disorders, mood and cognition. The final position of the active contacts of the implanted electrodes was investigated and side effects were reported. Three males and two females were included with a mean age of 41.6 years (SD 9.7). The total post-operative score on the Yale Global Tic Severity Scale was significantly lower than the pre-operative score (42.2±4.8 versus 12.8±3.8, P=0.043). There was also a significant reduction on the modified Rush Video-Based Tic Rating Scale (13.0±2.0 versus 7.0±1.6, P=0.041) and in the total number of video-rated tics...Continue Reading

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Citations

Aug 23, 2016·Brain Sciences·Ladan Akbarian-TefaghiThomas Foltynie
Apr 8, 2017·Journal of Neurosurgery·Richard S DowdAlon Y Mogilner
Jan 20, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Anouk Y J M SmeetsLinda Ackermans
Jun 25, 2017·Lancet Neurology·Marie-Laure WelterUNKNOWN STIC study group
Dec 9, 2017·F1000Research·Kevin J Black
Aug 9, 2017·Stereotactic and Functional Neurosurgery·Ladan Akbarian-TefaghiTom Foltynie
May 28, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Kara A JohnsonChristopher R Butson
Jun 16, 2018·F1000Research·Anne-Hélène ClairLuc Mallet
May 31, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Michal IsraelashviliIzhar Bar-Gad
Sep 19, 2019·Journal of Child Neurology·Wissam Deeb, Irene Malaty
May 28, 2019·Frontiers in Neurology·Stephanie CerneraAysegul Gunduz
Jan 21, 2020·Translational Neurodegeneration·Wenying XuBomin Sun
May 19, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Fengqiao SunJin Zhu

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