Deep brain stimulation of the posterior gyrus rectus region for treatment resistant depression

Journal of Affective Disorders
Ettore A AccollaBogdan Draganski

Abstract

Deep brain stimulation (DBS) represents an alternative symptomatic treatment for major depressive disorder in case of failure of pharmacotherapy. The sub-genual cingulate-Brodmann area 25 (CG-25), is one of the most widely used targets for electrode implantation. Given the diverging clinical outcome after DBS, there is a pressing need for in-depth study of brain anatomy and function allowing accurate and reliable prognosis before surgery. We studied five treatment-resistant major depressive disorder patients planned to undergo DBS targeting the CG-25. Before surgery, we acquired high-resolution magnetic resonance (MR) diffusion-weighted images for each patient followed by post-surgery MRI for electrode localization. To estimate individual anatomical connectivity pattern of the active contact location we performed probabilistic diffusion tractography intra-individually. We then correlated connectivity patterns with outcome assessed with standardized clinical tests. Connectivity results were compared between DBS responders and non-responders. We observed in one patient an excellent clinical response after DBS of the bilateral posterior gyrus rectus rather than the initially targeted CG-25. The remaining four patients with DBS of ...Continue Reading

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Citations

Jun 3, 2017·Social Cognitive and Affective Neuroscience·Wen-Hua LiuJonathan P Roiser
Apr 27, 2018·Depression and Anxiety·Steve KiselyDan Siskind
Oct 17, 2017·Frontiers in Surgery·Angela An Qi See, Nicolas Kon Kam King
Sep 3, 2020·Journal of Clinical Medicine·Frederick L HittiGordon H Baltuch
Aug 28, 2020·Journal of Clinical Medicine·Milaine RoetAli Jahanshahi
Oct 5, 2016·Experimental and Therapeutic Medicine·Kuanqing Mi
Jan 24, 2021·Human Brain Mapping·Evangelia TsolakiNader Pouratian
Mar 13, 2021·Current Behavioral Neuroscience Reports·Camilla L Nord
Aug 26, 2019·Magnetic Resonance Imaging·Ruoyun MaPierre-François Van de Moortele
Mar 25, 2021·Deutsches Ärzteblatt International·Thomas E SchläpferVolker A Coenen
May 8, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Saba AmiriMehdi M Mirbagheri
Nov 19, 2017·Journal of Affective Disorders·Trehani M FonsekaSidney H Kennedy

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