Deep brain stimulation of the substantia nigra pars reticulata exerts long lasting suppression of amygdala-kindled seizures

Brain Research
Li-Hong ShiJing-Yu Chang

Abstract

Deep brain stimulation (DBS) has been used to treat a variety of neurological disorders including epilepsy. However, we have limited knowledge about effective target areas, optimal stimulation parameters, and long-term effect of DBS on epileptic seizures. Here we examined the effects of DBS of the substantia nigra pars reticulata (SNr) on amygdala-kindled seizures. Microwire electrodes were implanted into the SNr and amygdala of adult male rats. When stage 5-kindled seizures were achieved by daily amygdala kindling, high frequency stimulation was delivered to the SNr bilaterally 1 s after cessation of kindling. Our DBS protocol completely blocked kindled seizures in 10 out of 23 (43.5%) rats studied. Furthermore, when the same amygdala kindling procedure was performed 24 h later without DBS, the kindling failed to elicit any seizure signs in 6 of these 10 rats. Some of the post-DBS period of seizure suppression lasted for up to 4 days. In other 3 rats, only mild stage 1 to 2 seizures appeared following amygdala kindling. Only 1 of the 10 rats for which DBS had blocked kindled seizures exhibited full-scale 5 stage-kindled seizures 24 h after DBS. These results suggest that highly plastic neural networks are involved in amygdala-...Continue Reading

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Citations

Oct 1, 2009·Neuromodulation : Journal of the International Neuromodulation Society·Sean Jeremy Nagel, Imad Michel Najm
Jan 25, 2008·Acta Pharmacologica Sinica·Li-li ZhangWing-ho Yung
Sep 2, 2008·Neurosurgical Focus·Thomas L Ellis, Andrew Stevens
Nov 30, 2015·Clinical Neurology and Neurosurgery·Neil V Klinger, Sandeep Mittal
Jun 30, 2009·Progress in Neurobiology·Paolo GubelliniChristelle Baunez
Mar 6, 2018·Neurology India·Paresh K Doshi
Mar 9, 2021·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Bing HuDingjiang Wang

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