Deep Brain Stimulation of the Subthalamic Nucleus Parameter Optimization for Vowel Acoustics and Speech Intelligibility in Parkinson's Disease

Journal of Speech, Language, and Hearing Research : JSLHR
Thea KnowlesMandar Jog

Abstract

The settings of 3 electrical stimulation parameters were adjusted in 12 speakers with Parkinson's disease (PD) with deep brain stimulation of the subthalamic nucleus (STN-DBS) to examine their effects on vowel acoustics and speech intelligibility. Participants were tested under permutations of low, mid, and high STN-DBS frequency, voltage, and pulse width settings. At each session, participants recited a sentence. Acoustic characteristics of vowel production were extracted, and naive listeners provided estimates of speech intelligibility. Overall, lower-frequency STN-DBS stimulation (60 Hz) was found to lead to improvements in intelligibility and acoustic vowel expansion. An interaction between speaker sex and STN-DBS stimulation was found for vowel measures. The combination of low frequency, mid to high voltage, and low to mid pulse width led to optimal speech outcomes; however, these settings did not demonstrate significant speech outcome differences compared with the standard clinical STN-DBS settings, likely due to substantial individual variability. Although lower-frequency STN-DBS stimulation was found to yield consistent improvements in speech outcomes, it was not found to necessarily lead to the best speech outcomes for...Continue Reading

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Citations

Apr 7, 2020·Expert Review of Medical Devices·Antonella MacerolloPatricia Limousin
Apr 9, 2021·Journal of Speech, Language, and Hearing Research : JSLHR·Anita SenthinathanMandar Jog
Sep 29, 2021·Journal of Speech, Language, and Hearing Research : JSLHR·Thea KnowlesMandar Jog
Nov 21, 2018·Journal of Voice : Official Journal of the Voice Foundation·Aline Nunes Da Cruz MorelloCarlos R M Rieder

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