Deep inhalation prevents the respiratory elastance response to methacholine in rats

Pediatric Research
Cyril SchweitzerF Marchal

Abstract

The bronchodilator effect of deep inhalation (DI) may be assessed from the time course of respiratory system resistance (Rrs) and reactance (Xrs) measured by the forced oscillation technique at a single frequency. The aim of the study was to assess the effect of DI in the closed chest rat. Under anesthesia and mechanical ventilation, seven Brown Norway rats were given regular DI (BN-di) and six underwent continuous tidal ventilation (BN) throughout an otherwise similar methacholine (Mch) challenge protocol. Rrs and Xrs were monitored at 20 Hz and apparent respiratory system elastance (Ers) was computed from Xrs. After Mch nebulization, there was a significant increase in Rrs and Ers compared with saline. Ers, but not Rrs, decreased after the DI and BN-di were found to have lower Ers than BN. Thus, DI significantly alters Ers and its response to Mch. Computer simulations suggested reversal of increased viscoelasticity and/or inhomogeneous behavior by the DI in that model.

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Citations

Sep 17, 2013·Respiratory Physiology & Neurobiology·I IoanS Varechova
Jun 28, 2011·Journal of Applied Physiology·Gwen SklootAlkis Togias
Nov 27, 2007·Respiratory Physiology & Neurobiology·François MarchalNoëlle Bertin
Jul 10, 2013·Respiratory Physiology & Neurobiology·G BarthelF Marchal
May 26, 2017·Experimental Lung Research·Feng ZhengOlivier Collange
May 16, 2009·Journal of Applied Physiology·David G ChapmanCheryl M Salome

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