Deep inspiration increases the absorption of inhaled sodium cromoglycate

British Journal of Clinical Pharmacology
R RichardsS T Holgate

Abstract

The plasma concentrations of sodium cromoglycate were measured for 4 h following a single dose of 20 mg given by inhalation to six normal volunteers. A series of forced expiratory manoeuvres was performed 2 h after the dose, which resulted in a rapid and marked increase in the plasma concentrations of the drug. A similar increase was found in three volunteers who undertook a single deep inspiration at 4 h. These data indicate that the absorption of cromoglycate from the airways can be affected by manoeuvres used to assess lung function.

References

Oct 1, 1986·British Journal of Clinical Pharmacology·M G NealeR M Auty
Oct 1, 1985·Journal of Applied Physiology·J D MarksJ F Murray
May 1, 1983·The Journal of Pharmacy and Pharmacology·R W Fuller, J G Collier
Mar 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·N W RizkJ F Murray
Jan 1, 1983·Annals of Clinical Biochemistry·K BrownD J Wilkinson

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Citations

May 10, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Elke KöhlerJürgen Hühnerbein
May 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Q A Summers

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