Deep Learning-Based Framework for In Vivo Identification of Glioblastoma Tumor using Hyperspectral Images of Human Brain

Sensors
Himar FabeloBaowei Fei

Abstract

The main goal of brain cancer surgery is to perform an accurate resection of the tumor, preserving as much normal brain tissue as possible for the patient. The development of a non-contact and label-free method to provide reliable support for tumor resection in real-time during neurosurgical procedures is a current clinical need. Hyperspectral imaging is a non-contact, non-ionizing, and label-free imaging modality that can assist surgeons during this challenging task without using any contrast agent. In this work, we present a deep learning-based framework for processing hyperspectral images of in vivo human brain tissue. The proposed framework was evaluated by our human image database, which includes 26 in vivo hyperspectral cubes from 16 different patients, among which 258,810 pixels were labeled. The proposed framework is able to generate a thematic map where the parenchymal area of the brain is delineated and the location of the tumor is identified, providing guidance to the operating surgeon for a successful and precise tumor resection. The deep learning pipeline achieves an overall accuracy of 80% for multiclass classification, improving the results obtained with traditional support vector machine (SVM)-based approaches. ...Continue Reading

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Citations

Mar 20, 2020·Journal of Magnetic Resonance Imaging : JMRI·Fabrício Guimarães GonçalvesSuyash Mohan
Mar 5, 2020·Scientific Reports·Alexandru GrigoroiuSarah E Bohndiek
Jul 6, 2020·Frontiers of Medicine·Allison J Navarrete-Welton, Daniel A Hashimoto
Sep 3, 2019·Frontiers in Oncology·Houman SotoudehGregory K Friedman
Mar 25, 2020·Biomedical Optics Express·Martin HalicekBaowei Fei
Feb 27, 2020·Brain Sciences·Muhammad Waqas NadeemSuhail Ashfaq Butt
Dec 15, 2020·Briefings in Bioinformatics·Ninon BurgosOlivier Colliot
Feb 6, 2021·Journal of Biomedical Informatics·Amir Ebrahimi ZadeM Soltani
May 25, 2021·Journal of Physics D: Applied Physics· Michael EbnerTom Vercauteren
Aug 31, 2021·Journal of Imaging·Taye Girma DebeleeZemene Matewos Shewarega
Oct 6, 2021·Scientific Reports·Raquel LeonGustavo M Callico
Dec 1, 2021·Science China. Life Sciences·Kai ChenErwei Song

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Methods Mentioned

BETA
biopsy
PCA
biopsies
surgical resection

Software Mentioned

MATLAB
SAM
MATLAB GUIDE
AdaDelta
TensorFlow

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