Deep learning-based identification of acute ischemic core and deficit from non-contrast CT and CTA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Chengyan WangHe Wang

Abstract

The accurate identification of irreversible infarction and salvageable tissue is important in planning the treatments for acute ischemic stroke (AIS) patients. Computed tomographic perfusion (CTP) can be used to evaluate the ischemic core and deficit, covering most of the territories of anterior circulation, but many community hospitals and primary stroke centers do not have the capability to perform CTP scan in emergency situation. This study aimed to identify AIS lesions from widely available non-contrast computed tomography (NCCT) and CT angiography (CTA) using deep learning. A total of 345AIS patients from our emergency department were included. A multi-scale 3D convolutional neural network (CNN) was used as the predictive model with inputs of NCCT, CTA, and CTA+ (8 s delay after CTA) images. An external cohort with 108 patients was included to further validate the generalization performance of the proposed model. Strong correlations with CTP-RAPID segmentations (r = 0.84 for core, r = 0.83 for deficit) were observed when NCCT, CTA, and CTA+ images were all used in the model. The diagnostic decisions according to DEFUSE3 showed high accuracy when using NCCT, CTA, and CTA+ (0.90±0.04), followed by the combination of NCCT and...Continue Reading

References

Dec 26, 2008·Stroke; a Journal of Cerebral Circulation·Jean-Marc OlivotGregory W Albers
Apr 29, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Shiliang HuangTimothy Q Duong
Nov 6, 2010·AJNR. American Journal of Neuroradiology·M SharmaR I Aviv
Aug 19, 2011·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Albert J YooPamela W Schaefer
Oct 8, 2011·Stroke; a Journal of Cerebral Circulation·Bruce C V CampbellMark W Parsons
Feb 12, 2015·The New England Journal of Medicine·Mayank GoyalUNKNOWN ESCAPE Trial Investigators
Nov 26, 2015·Radiology·Richard I AvivMax Wintermark
Dec 15, 2015·Journal of Neurointerventional Surgery·Fatih SekerMirko Pham
Dec 15, 2015·AJNR. American Journal of Neuroradiology·C ZernaM Goyal
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carlo W CeredaMaarten G Lansberg
Apr 20, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zachary B RodgersFelix W Wehrli
Feb 15, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jeremy J Heit, Max Wintermark
Mar 28, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Richard LeighPeter Cm van Zijl
Sep 29, 2017·Journal of Neurointerventional Surgery·Rui FengEric K Oermann
Oct 19, 2017·Journal of Stroke·Eun-Jae LeeDong-Wha Kang
Nov 14, 2017·The New England Journal of Medicine·Raul G NogueiraUNKNOWN DAWN Trial Investigators
Nov 28, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Chushuang ChenMark W Parsons
Jan 25, 2018·The New England Journal of Medicine·Gregory W AlbersUNKNOWN DEFUSE 3 Investigators
May 4, 2018·Stroke; a Journal of Cerebral Circulation·Anne NielsenKim Mouridsen
Aug 23, 2018·Clinical Neuroradiology·Meaghan ReidPhilip Barber
Jan 11, 2019·Stroke; a Journal of Cerebral Circulation·Elliot J TillingKeith W Muir
Feb 14, 2019·European Radiology Experimental·Olli ÖmanMarko Kangasniemi
Mar 21, 2019·Stroke; a Journal of Cerebral Circulation·JoonNyung HeoJi Hoe Heo
May 9, 2019·The New England Journal of Medicine·Henry MaUNKNOWN EXTEND Investigators
Jun 19, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carlos LaredoÁngel Chamorro
Sep 25, 2019·Stroke; a Journal of Cerebral Circulation·Sunil A ShethLuca Giancardo
Oct 1, 2019·CNS Neuroscience & Therapeutics·Carlos Garcia-EsperonUNKNOWN Northern NSW Telestroke investigators
Oct 9, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jinwei PangYong Jiang
May 7, 2020·CNS Neuroscience & Therapeutics·Li-Li CuiJohannes Boltze
Sep 11, 2019·Radiology. Artificial Intelligence·Raphael MeierJohannes Kaesmacher

❮ Previous
Next ❯

Methods Mentioned

BETA
feature extraction

Software Mentioned

Extensible Neuroimaging Archive Toolkit ( XNAT
CTA
DAWN
Linux ( Ubantu
iSchemaView
EXTEND
CTP
RAPID
DEFUSE3
TensorFlow

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.