Deep learning-based single-shot prediction of differential effects of anti-VEGF treatment in patients with diabetic macular edema

Biomedical Optics Express
Reza RastiSina Farsiu

Abstract

Anti-vascular endothelial growth factor (VEGF) agents are widely regarded as the first line of therapy for diabetic macular edema (DME) but are not universally effective. An automatic method that can predict whether a patient is likely to respond to anti-VEGF therapy can avoid unnecessary trial and error treatment strategies and promote the selection of more effective first-line therapies. The objective of this study is to automatically predict the efficacy of anti-VEGF treatment of DME in individual patients based on optical coherence tomography (OCT) images. We performed a retrospective study of 127 subjects treated for DME with three consecutive injections of anti-VEGF agents. Patients' retinas were imaged using spectral-domain OCT (SD-OCT) before and after anti-VEGF therapy, and the total retinal thicknesses before and after treatment were extracted from OCT B-scans. A novel deep convolutional neural network was designed and evaluated using pre-treatment OCT scans as input and differential retinal thickness as output, with 5-fold cross-validation. The group of patients responsive to anti-VEGF treatment was defined as those with at least a 10% reduction in retinal thickness following treatment. The predictive performance of ...Continue Reading

References

Jan 1, 1980·Cognitive Psychology·A M Treisman, G Gelade
Apr 30, 2010·Ophthalmology·UNKNOWN Diabetic Retinopathy Clinical Research NetworkJennifer K Sun
Feb 4, 2012·Diabetes Care·Joanne W Y YauUNKNOWN Meta-Analysis for Eye Disease (META-EYE) Study Group
Feb 23, 2012·Current Diabetes Reviews·Gian P Giuliari
Sep 3, 2013·Ophthalmology·Sina FarsiuUNKNOWN Age-Related Eye Disease Study 2 Ancillary Spectral Domain Optical Coherence Tomography Study Group
Nov 28, 2013·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Ana Rita SantosJosé Guilherme Cunha-Vaz
Aug 25, 2016·Journal of Ophthalmology·Guillaume LemaîtreDésiré Sidibé
May 6, 2017·IEEE Transactions on Medical Imaging·Wolf-Dieter VoglGeorg Langs
Jul 1, 2017·Investigative Ophthalmology & Visual Science·Hrvoje BogunovicUrsula Schmidt-Erfurth
Nov 7, 2017·Journal of Vitreoretinal Diseases·Ankoor R ShahJeremy D Wolfe
Nov 12, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Philipp PrahsDavid Märker
Apr 4, 2018·IEEE Transactions on Medical Imaging·Reza RastiFedra Hajizadeh
Aug 6, 2018·American Journal of Ophthalmology·Neil M BresslerUNKNOWN Diabetic Retinopathy Clinical Research Network
Aug 15, 2018·Nature Medicine·Jeffrey De FauwOlaf Ronneberger
Sep 28, 2018·The Journal of International Medical Research·Young Joo ChoMin Kim

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Citations

Aug 3, 2020·Current Opinion in Ophthalmology·Dinesh V GunasekeranTien Y Wong
Jul 9, 2020·Biomedical Optics Express·Cong WangDeyin Li
Aug 3, 2020·Current Opinion in Ophthalmology·Ashley KrasJohn B Miller
Jan 10, 2021·Ophthalmology and Therapy·Alessandro ArrigoFrancesco Bandello
Oct 24, 2020·International Ophthalmology Clinics·Meghana KalavarAjay E Kuriyan
Nov 24, 2020·Current Ophthalmology Reports·Brian E Goldhagen, Hasenin Al-Khersan
Jan 30, 2021·The Lancet. Digital Health·Dinesh V GunasekeranTien Y Wong
Oct 23, 2020·The British Journal of Ophthalmology·Martin MichlBianca S Gerendas
Mar 21, 2021·Survey of Ophthalmology·David Benet, Oscar J Pellicer-Valero
Jun 8, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Xinyu ZhaoYouxin Chen
Jun 25, 2021·Progress in Retinal and Eye Research·Ursula Schmidt-ErfurthHrvoje Bogunović

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