Deep-learning Classifier With an Ultrawide-field Scanning Laser Ophthalmoscope Detects Glaucoma Visual Field Severity

Journal of Glaucoma
Hiroki MasumotoHiroki Enno

Abstract

To evaluate the accuracy of detecting glaucoma visual field defect severity using deep-learning (DL) classifier with an ultrawide-field scanning laser ophthalmoscope. One eye of 982 open-angle glaucoma (OAG) patients and 417 healthy eyes were enrolled. We categorized glaucoma patients into 3 groups according to the glaucoma visual field damage (Humphrey Field Analyzer 24-2 program) [early; -6 dB (mean deviation) or better, moderate; between -6 and -12 dB, and severe as mean deviation of -12 dB or worse]. In total, 558 images (446 for training and 112 for grading) from early OAG patients, 203 images (162 for training and 41 for grading) from moderate OAG patients, 221 images (176 for training and 45 for grading) from severe OAG patients and 417 images (333 for training and 84 for grading) from normal subjects were analyzed using DL. The area under the receiver operating characteristic curve (AUC) was used to evaluate the accuracy after 100 trials. The mean AUC between normal versus all glaucoma patients was 0.872, the sensitivity was 81.3% and the specificity was 80.2%. In normal versus early OAG, mean AUC was 0.830, the sensitivity was 83.8% and the specificity was 75.3%. In normal versus moderate OAG, mean AUC was 0.864, sensi...Continue Reading

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Citations

Jul 6, 2019·Journal of Ophthalmology·Hiroki MasumotoAtsuki Fukushima
Feb 13, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hitoshi ImamuraSachiko Maruoka
Nov 5, 2020·NPJ Digital Medicine·Zhongwen LiHaotian Lin
Dec 11, 2020·NPJ Digital Medicine·Zhongwen LiHaotian Lin
Sep 9, 2020·Progress in Retinal and Eye Research·Ji-Peng Olivia LiDaniel S W Ting
Apr 4, 2021·Journal of Clinical Medicine·Tomofusa YamauchiHiroki Masumoto
Aug 21, 2021·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·T Y Alvin LiuNeil R Miller
Oct 12, 2021·Ophthalmology and Therapy·Yee Ling WongTariq M Aslam
Nov 5, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hitoshi TabuchiYoshiaki Kiuchi

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Software Mentioned

Optos
TensorFlow
Humphrey
ORIGA
CAM
Grad
JMP
Scipy

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