Deep Learning for Prediction of AMD Progression: A Pilot Study

Investigative Ophthalmology & Visual Science
Daniel B RussakoffSobha Sivaprasad

Abstract

To develop and assess a method for predicting the likelihood of converting from early/intermediate to advanced wet age-related macular degeneration (AMD) using optical coherence tomography (OCT) imaging and methods of deep learning. Seventy-one eyes of 71 patients with confirmed early/intermediate AMD with contralateral wet AMD were imaged with OCT three times over 2 years (baseline, year 1, year 2). These eyes were divided into two groups: eyes that had not converted to wet AMD (n = 40) at year 2 and those that had (n = 31). Two deep convolutional neural networks (CNN) were evaluated using 5-fold cross validation on the OCT data at baseline to attempt to predict which eyes would convert to advanced AMD at year 2: (1) VGG16, a popular CNN for image recognition was fine-tuned, and (2) a novel, simplified CNN architecture was trained from scratch. Preprocessing was added in the form of a segmentation-based normalization to reduce variance in the data and improve performance. Our new architecture, AMDnet, with preprocessing, achieved an area under the receiver operating characteristic (ROC) curve (AUC) of 0.89 at the B-scan level and 0.91 for volumes. Results for VGG16, an established CNN architecture, with preprocessing were 0.82...Continue Reading

References

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Citations

Apr 30, 2020·Asia-Pacific Journal of Ophthalmology·Dinesh Visva Gunasekeran, Tien Yin Wong
Aug 3, 2020·Current Opinion in Ophthalmology·Dinesh V GunasekeranTien Y Wong
May 20, 2020·Nature Medicine·Jason YimJeffrey De Fauw
Jul 25, 2020·Translational Vision Science & Technology·Daniel B RussakoffRobert T Chang
Nov 24, 2020·Current Ophthalmology Reports·Brian E Goldhagen, Hasenin Al-Khersan
Mar 27, 2021·Progress in Retinal and Eye Research·Tristan T HormelYali Jia
May 27, 2021·Translational Vision Science & Technology·Andrew C LinMichael B Gorin
Jun 3, 2021·International Journal of Molecular Sciences·Adrian DockeryG Jane Farrar
Jun 11, 2021·Translational Vision Science & Technology·Daniel Al MouieeMohit N Shivdasani
Jun 25, 2021·Progress in Retinal and Eye Research·Ursula Schmidt-ErfurthHrvoje Bogunović
Aug 19, 2021·Experimental Biology and Medicine·Kathleen RomondJoelle A Hallak
Nov 17, 2020·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Luísa S M MendonçaNadia K Waheed
Jan 23, 2022·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Matthias GutfleischDaniel Pauleikhoff

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