Deep learning for small and big data in psychiatry.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Georgia KoppeDaniel Durstewitz

Abstract

Psychiatry today must gain a better understanding of the common and distinct pathophysiological mechanisms underlying psychiatric disorders in order to deliver more effective, person-tailored treatments. To this end, it appears that the analysis of 'small' experimental samples using conventional statistical approaches has largely failed to capture the heterogeneity underlying psychiatric phenotypes. Modern algorithms and approaches from machine learning, particularly deep learning, provide new hope to address these issues given their outstanding prediction performance in other disciplines. The strength of deep learning algorithms is that they can implement very complicated, and in principle arbitrary predictor-response mappings efficiently. This power comes at a cost, the need for large training (and test) samples to infer the (sometimes over millions of) model parameters. This appears to be at odds with the as yet rather 'small' samples available in psychiatric human research to date (n < 10,000), and the ambition of predicting treatment at the single subject level (n = 1). Here, we aim at giving a comprehensive overview on how we can yet use such models for prediction in psychiatry. We review how machine learning approaches c...Continue Reading

References

Dec 23, 2000·Science·J B TenenbaumJ C Langford
Dec 23, 2000·Science·S T Roweis, L K Saul
Feb 13, 2001·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·E BaşarM Schürmann
Mar 29, 2003·Neural Networks : the Official Journal of the International Neural Network Society·M Kimura, R Nakano
Feb 26, 2005·Journal of Computer-aided Molecular Design·P J L'HeureuxS Y Yue
Mar 1, 2006·BMC Bioinformatics·Sudhir Varma, Richard Simon
Jun 13, 2006·Neural Computation·Geoffrey E HintonYee-Whye Teh
May 13, 1983·Science·S KirkpatrickM P Vecchi
Feb 5, 2008·IEEE Transactions on Neural Networks·Y BengioR Ducharme
Feb 6, 2008·IEEE Transactions on Neural Networks·S Bengio, Y Bengio
Jan 1, 1996·IEEE Transactions on Neural Networks·Y Bengio, P Frasconi
Jan 1, 1993·IEEE Transactions on Neural Networks·J de Villiers, E Barnard
Jan 1, 1994·IEEE Transactions on Neural Networks·Y BengioP Frasconi
Jan 1, 1991·IEEE Transactions on Neural Networks·K S Narendra, K Parthasarathy
Jul 3, 2010·The American Journal of Psychiatry·Thomas InselPhilip Wang
Aug 19, 2010·The International Journal of Neuropsychopharmacology·Erik H F WongChi-Ming Lee
Sep 24, 2010·Psychological Medicine·K S KendlerC Craver
Feb 7, 2012·Neuroscience and Biobehavioral Reviews·Graziella OrrùAndrea Mechelli
Jan 2, 2013·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Zoubin Ghahramani
Mar 6, 2013·Cognitive Therapy and Research·Stefan G HofmannAngela Fang
Jun 22, 2013·IEEE Transactions on Pattern Analysis and Machine Intelligence·Yoshua BengioPascal Vincent
Jun 22, 2013·IEEE Transactions on Pattern Analysis and Machine Intelligence·Clément FarabetYann Lecun
Mar 1, 2014·Medical Image Computing and Computer-assisted Intervention : MICCAI·Dan C CireşanJürgen Schmidhuber
Jul 22, 2014·NeuroImage·Heung-Il SukUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 3, 2014·Neural Networks : the Official Journal of the International Neural Network Society·Jürgen Schmidhuber
Jan 18, 2015·Neural Networks : the Official Journal of the International Neural Network Society·Yoshua Bengio, Honglak Lee
Feb 5, 2015·JAMA Psychiatry·Madeleine GoodkindAmit Etkin
May 29, 2015·Nature·Yann LeCunGeoffrey Hinton
Jul 15, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Umut Güçlü, Marcel A J van Gerven
Aug 21, 2015·Child Development Perspectives·Charles Hulme, Margaret J Snowling
Jan 19, 2016·Frontiers in Systems Neuroscience·Ksenia P SolovyevaWitali L Dunin-Barkowski
Feb 26, 2016·Nature Neuroscience·Quentin J M HuysMichael J Frank
Mar 16, 2016·Biometrika·Lucas JansonTrevor J Hastie
Mar 24, 2016·Molecular Pharmaceutics·Polina MamoshinaAlex Zhavoronkov
Apr 12, 2016·Frontiers in Psychiatry·Hugo G Schnack, René S Kahn
Apr 15, 2016·Nature Communications·Noriaki YahataMitsuo Kawato
May 18, 2016·Neural Networks : the Official Journal of the International Neural Network Society·Adam P Trischler, Gabriele M T D'Eleuterio
Jun 28, 2016·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Vince D Calhoun, Jing Sui
Jul 1, 2016·Nature·Richard Van Noorden
Nov 7, 2016·JMIR MHealth and UHealth·Aarti SathyanarayanaShahrad Taheri
Dec 19, 2016·NeuroImage·Gaël VaroquauxBertrand Thirion

❮ Previous
Next ❯

Citations

Sep 29, 2020·The British Journal of Psychiatry : the Journal of Mental Science·Derek K TracySukhwinder S Shergill
Sep 13, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kerry J Ressler, Leanne M Williams
Apr 23, 2021·Cerebral Cortex·Yanhui DingUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jun 4, 2021·The American Journal of Psychiatry·Adrienne GrzendaAlik S Widge
Sep 11, 2021·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·John TorousJoseph Firth

❮ Previous
Next ❯

Software Mentioned

ABIDE
SGD
OASIS
Adam
ADNI
AdaGrad
VGGNet
ENIGMA
AlexNet

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Magnetic Resonance
Jeffrey C Hoch
Physical Chemistry Chemical Physics : PCCP
Usant KajendirarajahFrançois Lagugné-Labarthet
© 2021 Meta ULC. All rights reserved