Deep learning improves antimicrobial peptide recognition

Bioinformatics
Daniel VeltriAmarda Shehu

Abstract

Bacterial resistance to antibiotics is a growing concern. Antimicrobial peptides (AMPs), natural components of innate immunity, are popular targets for developing new drugs. Machine learning methods are now commonly adopted by wet-laboratory researchers to screen for promising candidates. In this work, we utilize deep learning to recognize antimicrobial activity. We propose a neural network model with convolutional and recurrent layers that leverage primary sequence composition. Results show that the proposed model outperforms state-of-the-art classification models on a comprehensive dataset. By utilizing the embedding weights, we also present a reduced-alphabet representation and show that reasonable AMP recognition can be maintained using nine amino acid types. Models and datasets are made freely available through the Antimicrobial Peptide Scanner vr.2 web server at www.ampscanner.com. Supplementary data are available at Bioinformatics online.

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Citations

Jan 25, 2019·Current Topics in Medicinal Chemistry·Qihui WuJingwei Zhou
Sep 26, 2019·Protein and Peptide Letters·Mithoor DivyashreeDebmalya Barh
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