Deep learning radiomics can predict axillary lymph node status in early-stage breast cancer.

Nature Communications
Xueyi ZhengJianhua Zhou

Abstract

Accurate identification of axillary lymph node (ALN) involvement in patients with early-stage breast cancer is important for determining appropriate axillary treatment options and therefore avoiding unnecessary axillary surgery and complications. Here, we report deep learning radiomics (DLR) of conventional ultrasound and shear wave elastography of breast cancer for predicting ALN status preoperatively in patients with early-stage breast cancer. Clinical parameter combined DLR yields the best diagnostic performance in predicting ALN status between disease-free axilla and any axillary metastasis with areas under the receiver operating characteristic curve (AUC) of 0.902 (95% confidence interval [CI]: 0.843, 0.961) in the test cohort. This clinical parameter combined DLR can also discriminate between low and heavy metastatic burden of axillary disease with AUC of 0.905 (95% CI: 0.814, 0.996) in the test cohort. Our study offers a noninvasive imaging biomarker to predict the metastatic extent of ALN for patients with early-stage breast cancer.

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Citations

Feb 4, 2021·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Matthias DietzelPascal Andreas Thomas Baltzer
Jan 31, 2021·Nature Reviews. Cancer·Andreas KleppeHåvard E Danielsen
Jan 30, 2021·Seminars in Nuclear Medicine·Mathieu HattDimitris Visvikis
Jan 13, 2021·Ultrasonography·Jaeil KimWon Hwa Kim
Mar 26, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Panagiotis PapadimitroulasMathieu Hatt
May 8, 2021·European Journal of Radiology·Yu-Ting ShenHui-Xiong Xu
May 28, 2021·Breast Cancer : Targets and Therapy·Michael Y Chen, William E Gillanders
Jul 1, 2021·European Journal of Hybrid Imaging·Hossein Arabi, Habib Zaidi
Aug 10, 2021·Frontiers in Oncology·Yu-Meng LeiChristoph F Dietrich
Aug 22, 2021·Ultrasonic Imaging·Aylin TahmasebiJohn R Eisenbrey
Nov 13, 2021·Frontiers in Aging Neuroscience·Ping ZhouUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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Methods Mentioned

BETA
dissection
biopsy

Software Mentioned

DLR
MedCalc
matlab
Imagenet
Python

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