Deep molecular diversity of mammalian synapses: why it matters and how to measure it.

Nature Reviews. Neuroscience
Nancy A O'RourkeStephen J Smith

Abstract

Pioneering studies in the middle of the twentieth century revealed substantial diversity among mammalian chemical synapses and led to a widely accepted classification of synapse type on the basis of neurotransmitter molecule identity. Subsequently, powerful new physiological, genetic and structural methods have enabled the discovery of much deeper functional and molecular diversity within each traditional neurotransmitter type. Today, this deep diversity continues to pose both daunting challenges and exciting new opportunities for neuroscience. Our growing understanding of deep synapse diversity may transform how we think about and study neural circuit development, structure and function.

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S M Dudek, M F Bear
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y A Ushkaryov, T C Südhof
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·K D Micheva, C Beaulieu
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·J Y SongN Brose
Apr 9, 1999·Nature Neuroscience·A ReyesB Sakmann
Jan 13, 2000·Archives of General Psychiatry·L A Glantz, D A Lewis
May 18, 2000·Human Molecular Genetics·J K MillarD J Porteous
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·O CaillardA Marty
Apr 3, 2001·Trends in Pharmacological Sciences·U RudolphH Möhler
Jan 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·John J RengerTakao K Hensch
Dec 20, 2002·Nature·Jaime GrutzendlerWen-Biao Gan
Jun 26, 2003·The European Journal of Neuroscience·Taisuke MiyazakiMasahiko Watanabe
Dec 4, 2003·Médecine sciences : M/S·Stéphane JamainThomas Bourgeron
Mar 17, 2004·The Journal of Biological Chemistry·Junmin PengMorgan Sheng
Sep 21, 2004·Nature Reviews. Neuroscience·Henry MarkramCaizhi Wu
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Oct 21, 2004·Science's STKE : Signal Transduction Knowledge Environment·Stuart G Cull-Candy, Daniel N Leszkiewicz
Nov 16, 2004·European Journal of Cell Biology·Frédérique VaroqueauxNils Brose
Apr 12, 2005·Cell Calcium·Nail Burnashev, Andrei Rozov
Jun 29, 2005·Proteomics·Sabine P SchrimpfPeter Sonderegger
Dec 22, 2005·Nature Neuroscience·Ken SuginoSacha B Nelson
Mar 2, 2006·Molecular & Cellular Proteomics : MCP·Dongmei ChengJunmin Peng
Mar 21, 2006·Nature Neuroscience·Yun WangPatricia S Goldman-Rakic
Jun 1, 2006·The Journal of Comparative Neurology·Brian KirkpatrickRosalinda C Roberts
Jun 17, 2006·Annual Review of Neuroscience·Vivien ChevaleyrePablo E Castillo

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Citations

Sep 18, 2012·Molecular Neurobiology·Bence Rácz, Richard J Weinberg
Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Margaret T ButkoRoger Y Tsien
Apr 5, 2013·PLoS Computational Biology·Brad Busse, Stephen Smith
Jun 11, 2014·Cellular and Molecular Life Sciences : CMLS·John Jia En Chua
Jun 1, 2013·Nature Methods·Pavel Osten, Troy W Margrie
Oct 28, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ralf Der, Georg Martius
Dec 3, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Hannah DueckJunhyong Kim
Jan 23, 2013·Neurobiology of Disease·Saurav SeshadriAkira Sawa
Nov 21, 2012·Trends in Neurosciences·Stefan Hallermann, R Angus Silver
Jan 21, 2014·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Brian R LongHaining Zhong
Mar 19, 2014·The Journal of Comparative Neurology·Alain C BuretteRichard J Weinberg
Dec 3, 2014·Current Biology : CB·Astrid G Petzoldt, Stephan J Sigrist
Aug 19, 2015·Frontiers in Neuroanatomy·Alain BuretteRichard J Weinberg
Aug 19, 2015·Frontiers in Neural Circuits·Mariano Soiza-ReillyBenjamin R Arenkiel
Feb 28, 2015·Experimental Cell Research·Katrin MichelSusanne Schoch
Sep 11, 2014·Frontiers in Neural Circuits·Mariano Soiza-Reilly, Kathryn G Commons
May 21, 2016·Frontiers in Cellular Neuroscience·Christopher HeiseTobias M Boeckers
Aug 17, 2016·PloS One·Johany PeñaililloDaniela Seelenfreund
Oct 11, 2016·Brain Research Bulletin·Marco Sassoè-Pognetto, Annarita Patrizi
Jan 13, 2017·PLoS Computational Biology·Eric Jonas, Konrad Paul Kording
Aug 27, 2015·Molecular & Cellular Proteomics : MCP·Daniela C Dieterich, Michael R Kreutz
Nov 28, 2017·Brain : a Journal of Neurology·Martí Colom-CadenaAlberto Lleó
May 1, 2018·Neural Plasticity·María Verónica BaezDiana Alicia Jerusalinsky
Apr 10, 2018·Experimental & Molecular Medicine·Anna Schroeder, Joris de Wit
Dec 31, 2015·Nature Protocols·László BarnaIstván Katona
Oct 29, 2014·Nature Neuroscience·Robert R KitchenAngus C Nairn
Oct 29, 2014·Nature Neuroscience·Jeff W LichtmanNir Shavit
Nov 21, 2012·Nature Reviews. Neuroscience·Miguel L ConchaStephen W Wilson
Mar 19, 2016·Nature Reviews. Neuroscience·Jinwei ZhuMingjie Zhang
Apr 26, 2019·PLoS Computational Biology·Renato Duarte, Abigail Morrison
Jun 5, 2019·Cell Transplantation·Abraam M Yakoub, Mark Sadek

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