Deep phenotyping to predict live birth outcomes in in vitro fertilization.

Proceedings of the National Academy of Sciences of the United States of America
Prajna BanerjeeMylene W M Yao

Abstract

Nearly 75% of in vitro fertilization (IVF) treatments do not result in live births and patients are largely guided by a generalized age-based prognostic stratification. We sought to provide personalized and validated prognosis by using available clinical and embryo data from prior, failed treatments to predict live birth probabilities in the subsequent treatment. We generated a boosted tree model, IVFBT, by training it with IVF outcomes data from 1,676 first cycles (C1s) from 2003-2006, followed by external validation with 634 cycles from 2007-2008, respectively. We tested whether this model could predict the probability of having a live birth in the subsequent treatment (C2). By using nondeterministic methods to identify prognostic factors and their relative nonredundant contribution, we generated a prediction model, IVF(BT), that was superior to the age-based control by providing over 1,000-fold improvement to fit new data (p<0.05), and increased discrimination by receiver-operative characteristic analysis (area-under-the-curve, 0.80 vs. 0.68 for C1, 0.68 vs. 0.58 for C2). IVFBT provided predictions that were more accurate for approximately 83% of C1 and approximately 60% of C2 cycles that were out of the range predicted by a...Continue Reading

References

Oct 1, 1986·Fertility and Sterility·D S GuzickH W Jones
Nov 23, 1996·Lancet·A TempletonW Parslow
Jan 11, 2000·Clinical Obstetrics and Gynecology·J F Randolph
Oct 27, 2001·Seminars in Reproductive Medicine·J Collins
Jan 17, 2002·The New England Journal of Medicine·D S GuzickUNKNOWN National Cooperative Reproductive Medicine Network
Feb 12, 2005·Internal Medicine Journal·R P S Jansen
Jun 14, 2006·Best Practice & Research. Clinical Obstetrics & Gynaecology·Petra De Sutter
Aug 31, 2006·Human Reproduction Update·C M VerhaakD D M Braat
Jan 15, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·Y KhalafP Braude
Jul 4, 2008·PloS One·Sunny H JunMylene W M Yao
Nov 8, 2008·Science·David AltshulerEric S Lander
Jan 16, 2009·The New England Journal of Medicine·Beth A MaliziaAlan S Penzias
May 14, 2009·Human Reproduction Update·Esther LeushuisPeter G A Hompes

❮ Previous
Next ❯

Citations

Jan 23, 2014·Reproductive Biomedicine Online·Piraye Yurttas BeimTina T Hu-Seliger
Jan 12, 2013·Nature Protocols·Thomas O'LearySusana M Chuva de Sousa Lopes
Jul 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael LeBlanc, Charles Kooperberg
Sep 5, 2013·Journal of the American Medical Informatics Association : JAMIA·Mary Regina BolandChunhua Weng
Aug 9, 2013·Human Reproduction·L L van LoenderslootF van der Veen
Jun 8, 2012·Fertility and Sterility·Benjamin M LannonAlan S Penzias
Mar 26, 2013·Fertility and Sterility·Bokyung ChoiMylene W M Yao
Jul 29, 2018·Journal of Assisted Reproduction and Genetics·Mara SimopoulouMichael Koutsilieris
Jun 21, 2019·Journal of Assisted Reproduction and Genetics·Paraskevi VogiatziCharalampos Siristatidis
Jun 18, 2017·Fertility Research and Practice·Tamara TobiasEmily Pinckney-Clark
Apr 10, 2019·Human Fertility : Journal of the British Fertility Society·Yanhe LiuPhillip Matson
Nov 1, 2020·Biometrics·Ariel AlonsoGeert Molenberghs
Aug 21, 2020·Reproductive Biomedicine Online·Julian JenkinsMylene M W Yao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.