Abstract
About 25% of schizophrenia patients with auditory hallucinations are refractory to pharmacotherapy and electroconvulsive therapy. We conducted a deep transcranial magnetic stimulation (TMS) pilot study in order to evaluate the potential clinical benefit of repeated left temporoparietal cortex stimulation in these patients. The results were encouraging, but a sham-controlled study was needed to rule out a placebo effect. A total of 18 schizophrenic patients with refractory auditory hallucinations were recruited, from Beer Yaakov MHC and other hospitals outpatient populations. Patients received 10 daily treatment sessions with low-frequency (1 Hz for 10 min) deep TMS applied over the left temporoparietal cortex, using the H1 coil at the intensity of 110% of the motor threshold. Procedure was either real or sham according to patient randomization. Patients were evaluated via the Auditory Hallucinations Rating Scale, Scale for the Assessment of Positive Symptoms-Negative Symptoms, Clinical Global Impressions, and Quality of Life Questionnaire. In all, 10 patients completed the treatment (10 TMS sessions). Auditory hallucination scores of both groups improved; however, there was no statistical difference in any of the scales between...Continue Reading
References
Aug 28, 1998·Schizophrenia Research·S S ShergillP K McGuire
Jul 8, 1999·Biological Psychiatry·R E HoffmanD S Charney
Nov 25, 2000·Psychiatry Research·B R LennoxP B Jones
Nov 19, 2002·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Yiftach RothMark Hallett
Jan 18, 2005·Biological Psychiatry·Emmanuel PouletMohamed Saoud
Mar 29, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Abraham ZangenMark Hallett
Feb 6, 2007·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Yiftach RothAbraham Zangen
Nov 6, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yechiel LevkovitzAbraham Zangen
Aug 7, 2009·Psychological Medicine·C K LooP S Sachdev
May 11, 2010·Depression and Anxiety·O RosenbergP N Dannon
Jul 17, 2010·Brain Stimulation·Yechiel LevkovitzAbraham Zangen
Jul 29, 2010·Journal of Affective Disorders·Moshe IsserlesAbraham Zangen
Oct 23, 2010·Brain Stimulation·Oded RosenbergPinhas N Dannon
Dec 15, 2010·Biological Psychiatry·Christina W SlotemaIris E C Sommer
Feb 10, 2011·Annals of General Psychiatry·Oded RosenbergPinhas Dannon
Mar 1, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·O RosenbergP N Dannon
Apr 29, 2011·The International Journal of Neuropsychopharmacology·Yechiel LevkovitzAbraham Zangen
Citations
Dec 10, 2013·Biological Psychiatry·Christina W SlotemaIris E C Sommer
Nov 4, 2015·Frontiers in Systems Neuroscience·Katharina M KuberaRobert C Wolf
Apr 27, 2016·Epilepsy & Behavior Case Reports·R GersnerA Rotenberg
Dec 18, 2016·Acta Psychiatrica Scandinavica·M-L Paillère-MartinotE Artiges
Aug 21, 2015·The Cochrane Database of Systematic Reviews·Nadine DougallAndrew McIntosh
Dec 3, 2014·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Derek K TracySukhwinder S Shergill
Aug 15, 2019·Current Psychiatry Reports·Urvakhsh Meherwan MehtaJagadisha Thirthalli