Deep transcranial magnetic stimulation add-on for the treatment of auditory hallucinations: a double-blind study.

Annals of General Psychiatry
Oded RosenbergPinhas Dannon

Abstract

About 25% of schizophrenia patients with auditory hallucinations are refractory to pharmacotherapy and electroconvulsive therapy. We conducted a deep transcranial magnetic stimulation (TMS) pilot study in order to evaluate the potential clinical benefit of repeated left temporoparietal cortex stimulation in these patients. The results were encouraging, but a sham-controlled study was needed to rule out a placebo effect. A total of 18 schizophrenic patients with refractory auditory hallucinations were recruited, from Beer Yaakov MHC and other hospitals outpatient populations. Patients received 10 daily treatment sessions with low-frequency (1 Hz for 10 min) deep TMS applied over the left temporoparietal cortex, using the H1 coil at the intensity of 110% of the motor threshold. Procedure was either real or sham according to patient randomization. Patients were evaluated via the Auditory Hallucinations Rating Scale, Scale for the Assessment of Positive Symptoms-Negative Symptoms, Clinical Global Impressions, and Quality of Life Questionnaire. In all, 10 patients completed the treatment (10 TMS sessions). Auditory hallucination scores of both groups improved; however, there was no statistical difference in any of the scales between...Continue Reading

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References

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May 11, 2010·Depression and Anxiety·O RosenbergP N Dannon
Oct 23, 2010·Brain Stimulation·Oded RosenbergPinhas N Dannon
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Apr 29, 2011·The International Journal of Neuropsychopharmacology·Yechiel LevkovitzAbraham Zangen

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Citations

Dec 10, 2013·Biological Psychiatry·Christina W SlotemaIris E C Sommer
Aug 21, 2015·The Cochrane Database of Systematic Reviews·Nadine DougallAndrew McIntosh
Dec 3, 2014·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Derek K TracySukhwinder S Shergill
Aug 15, 2019·Current Psychiatry Reports·Urvakhsh Meherwan MehtaJagadisha Thirthalli

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