Deep transcranial magnetic stimulation (DTMS) in the treatment of major depression: An exploratory systematic review and meta-analysis

Journal of Affective Disorders
Karina Karolina KedziorMarcelo T Berlim

Abstract

Deep transcranial magnetic stimulation (DTMS) is a relatively new, non-invasive method of stimulating larger and, presumably, deeper brain regions. The current study investigated if DTMS delivered with H-coils has acute antidepressant effects in major depression using a systematic literature review and a quantitative meta-analysis. Seventeen studies on 'DTMS or H-coil' and 'depression' were identified on Medline, PsycInfo, and Google Scholar (until November 2014). Data from nine open-label studies were meta-analysed using a random-effects model with inverse-variance weights. The outcome measures were the standardised paired mean difference (Cohen's d) in depression scores on Hamilton Depression Rating Scale (HDRS), response, remission, and dropout rates after acute DTMS treatment compared to baseline. There was a large antidepressant effect after 20 acute, high-frequency DTMS sessions compared to baseline according to HDRS change scores (overall mean weighted d=2.04, 95% confidence interval: 1.53-2.55; nine studies; 150 patients). Overall weighted response, remission, and dropout rates were 60%, 29%, and 18% respectively. HDRS change scores and response rates tended to be higher in four studies with 68 patients on concurrent an...Continue Reading

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Citations

Feb 6, 2016·Annals of the New York Academy of Sciences·Katharine DunlopJonathan Downar
Feb 2, 2016·Journal of Psychiatric Research·Karina Karolina KedziorMarcelo T Berlim
Apr 20, 2016·Nordic Journal of Psychiatry·Axel NordenskjöldMikael Landén
Jun 10, 2017·Expert Review of Neurotherapeutics·Gopalkumar RakeshPrakash S Masand
Feb 11, 2018·Current Psychiatry Reports·Ilva G Iriarte, Mark S George
Sep 27, 2018·Cold Spring Harbor Perspectives in Medicine·Sarah A Stanley, Jeffrey M Friedman

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