Deep Tumor Penetration of Drug-Loaded Nanoparticles by Click Reaction-Assisted Immune Cell Targeting Strategy

Journal of the American Chemical Society
Soo Hong LeeTaeghwan Hyeon

Abstract

Nanoparticles have been extensively used to deliver therapeutic drugs to tumor tissues through the extravasation of a leaky vessel via enhanced permeation and retention effect (EPR, passive targeting) or targeted interaction of tumor-specific ligands (active targeting). However, the therapeutic efficacy of drug-loaded nanoparticles is hampered by its heterogeneous distribution owing to limited penetration in tumor tissue. Inspired by the fact that cancer cells can recruit inflammatory immune cells to support their survival, we developed a click reaction-assisted immune cell targeting (CRAIT) strategy to deliver drug-loaded nanoparticles deep into the avascular regions of the tumor. Immune cell-targeting CD11b antibodies are modified with trans-cyclooctene to enable bioorthogonal click chemistry with mesoporous silica nanoparticles functionalized with tetrazines (MSNs-Tz). Sequential injection of modified antibodies and MSNs-Tz at intervals of 24 h results in targeted conjugation of the nanoparticles onto CD11b+ myeloid cells, which serve as active vectors into tumor interiors. We show that the CRAIT strategy allows the deep tumor penetration of drug-loaded nanoparticles, resulting in enhanced therapeutic efficacy in an orthotop...Continue Reading

References

Feb 1, 1988·British Journal of Cancer·P M KellyJ O McGee
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·U KettlingM Eigen
Dec 2, 2004·Blood·Rika OkamotoNobuyuki Takakura
Jul 25, 2006·Nature Reviews. Cancer·Andrew I Minchinton, Ian F Tannock
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Feb 12, 2009·ACS Nano·Omid C Farokhzad, Robert Langer
Apr 7, 2009·Nano Letters·Steven D PerraultWarren C W Chan
Sep 8, 2009·Comparative Immunology, Microbiology and Infectious Diseases·Londa J BerghausGeert-Jan Boons
Mar 31, 2010·Chemical Society Reviews·John C Jewett, Carolyn R Bertozzi
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Steven D Perrault, Warren C W Chan
Sep 15, 2010·Nature Reviews. Clinical Oncology·Rakesh K Jain, Triantafyllos Stylianopoulos
Sep 30, 2010·The Journal of Experimental Medicine·Cesar A CorzoDmitry I Gabrilovich
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Cliff WongDai Fukumura
Jun 2, 2011·Accounts of Chemical Research·Neal K Devaraj, Ralph Weissleder
Dec 24, 2011·Nature Reviews. Cancer·Avi SchroederDaniel G Anderson
Feb 10, 2012·Chemical Society Reviews·Yue PanBing Xu
Mar 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Neal K DevarajRalph Weissleder
Mar 17, 2012·Journal of the American Chemical Society·Limin PanJianlin Shi
Mar 24, 2012·Cancer Cell·Douglas Hanahan, Lisa M Coussens
Aug 28, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chan Gi PackYasushi Sako
Dec 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hui ZhouJau-Shyong Hong
Sep 21, 2013·Nature·Melissa R Junttila, Frederic J de Sauvage
Oct 24, 2013·Nature Materials·Vikash P Chauhan, Rakesh K Jain
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Nov 26, 2013·Advanced Drug Delivery Reviews·Nicolas BertrandOmid C Farokhzad
Apr 15, 2014·Nature Nanotechnology·Bryan Ronain SmithSanjiv Sam Gambhir
Apr 4, 2015·Science·Steven A Rosenberg, Nicholas P Restifo
Jun 13, 2015·Science Translational Medicine·Bonnie HuangDarrell J Irvine
Oct 28, 2015·Nature Communications·Miles A MillerRalph Weissleder
Nov 20, 2015·Science Translational Medicine·Miles A MillerRalph Weissleder
Feb 16, 2016·Nature Nanotechnology·Yu MatsumotoKazunori Kataoka

❮ Previous
Next ❯

Citations

Mar 29, 2020·Chemistry : a European Journal·Song YuTrevor A Hamlin
Dec 15, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Puneet Tyagi
Jan 29, 2021·Biomedicines·Su Woong YooEuiheon Chung
Mar 30, 2021·Colloids and Surfaces. B, Biointerfaces·Arpan PradhanDulal Panda
Jun 16, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Yutong ShaoFengling Song
Jun 18, 2021·Nano-micro Letters·Qinjun ChenChen Jiang
Dec 24, 2019·ACS Nano·Zijian ZhouXiaoyuan Chen
Aug 19, 2020·ACS Applied Materials & Interfaces·Wu-Yi XiaoHao Wang
Oct 10, 2021·Advanced Healthcare Materials·Zhaoyu MaHeyou Han

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Magdalena AlevChristina Janko
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Lian-dong DengAn-jie Dong
Journal of Controlled Release : Official Journal of the Controlled Release Society
Kinam Park
© 2021 Meta ULC. All rights reserved