Deep venous thrombosis in children with musculoskeletal infections: the clinical evidence

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Elpis MantadakisMatthew E Falagas

Abstract

Clinical manifestations of deep venous thrombosis (DVT) tend to overlap with those of deep-seated musculoskeletal infections (MSIs). Consequently, the incidence of DVT as a complication of MSI may be underestimated. The objective of this study was to evaluate the incidence, clinical features, and outcomes of MSI-related DVT in children. We systematically reviewed relevant studies retrieved from PubMed and Scopus databases. Overall, 93 children with MSIs who developed DVT were identified from 28 retrospective studies. The majority were boys. Osteomyelitis was the most frequent MSI (69/74, 93%). Staphylococcus aureus was the predominant pathogen (83/93, 89%); 61% of these isolates were methicillin-resistant S. aureus (MRSA). Pulmonary involvement, presumably due to septic emboli, was observed in 65% of the included children. Four children died due to multiple organ failure and two due to respiratory distress. In two of the three studies providing comparative data, MRSA infections were observed significantly more frequently in children who developed DVT compared to those who did not. Yet, the respective differences observed for methicillin-susceptible S. aureus (MSSA) infections were non-significant in these three studies. Despite...Continue Reading

References

Nov 1, 1971·The Journal of Pediatrics·F L HorvathJ D Cherry
Nov 1, 1982·The Journal of Pediatrics·J B JupiterD Keim
Jan 1, 1997·Journal of Pediatric Surgery·L SmithS Walsh
Nov 20, 2001·The Journal of Pediatrics·C H van OmmenM Peters
Apr 19, 2002·Journal of Pediatric Orthopedics·Stewart Walsh, Fredrick Phillips
Jun 18, 2002·Pediatric Emergency Care·Craig D NewgardRichard Mink
Aug 6, 2004·The Pediatric Infectious Disease Journal·Gerardo Martínez-AguilarSheldon L Kaplan
Oct 20, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Hasan YükselMine Cabuk
Oct 28, 2004·Thrombosis Research·Charles T Esmon
May 3, 2006·Pediatrics·Blanca E GonzalezSheldon L Kaplan
Jul 22, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Niraj Procopio Evagrio GeorgeJulia M Ross
Oct 3, 2006·The Journal of Pediatrics·Shelley E CraryJanna M Journeycake
Jul 4, 2007·The Journal of Bone and Joint Surgery. American Volume·S Tyler HollmigPhilip L Wilson
Dec 8, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Steven W KerriganDermot Cox
Jun 27, 2008·Journal of Pediatric Orthopedics·Jesús Saavedra-LozanoOctavio Ramilo
Jan 20, 2009·Heart & Lung : the Journal of Critical Care·Betul TavilAytemiz Gurgey
Jan 1, 2008·Forensic Science, Medicine, and Pathology·Guy N Rutty
Apr 4, 2009·European Journal of Pediatrics·Kalomoira Kefala-AgoropoulouEmmanuel Roilides
Apr 23, 2009·International Journal of Emergency Medicine·Amy A LePageRaquel M Schears
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tobias A FuchsDenisa D Wagner
Sep 3, 2010·The Journal of Bone and Joint Surgery. American Volume·John E McDonald, Lawson A B Copley
Sep 14, 2010·Orthopaedics & Traumatology, Surgery & Research : OTSR·S BouchouchaM B Ghachem

❮ Previous
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Citations

Jan 22, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K Z VardakasM E Falagas
Jan 24, 2014·The New England Journal of Medicine·Heikki Peltola, Markus Pääkkönen
Mar 14, 2013·Pediatric Clinics of North America·Markus Pääkkönen, Heikki Peltola
Nov 28, 2013·Pediatrics and Neonatology·Chih-Ying LeeWen-Jue Soong
Dec 3, 2014·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·J Saavedra-LozanoL García
May 20, 2014·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·M Vargas-GutierrezR Ulloa-Gutierrez
Oct 21, 2016·JBJS Reviews·Thomas J AnJonathan G Schoenecker
May 18, 2017·Radiology·Diego JaramilloJoseph W St Geme
Jul 15, 2017·The Pediatric Infectious Disease Journal·Jesús Saavedra-LozanoAnton LeMair
Dec 5, 2017·Journal of Pediatric Hematology/oncology·Divyaswathi Citla SridharNidra I Rodriguez
Oct 10, 2018·Journal of Pediatric Orthopedics·Emilie AmaroJonathan G Schoenecker
Jan 4, 2013·Current Opinion in Pediatrics·Emily R Dodwell
Apr 16, 2014·Current Opinion in Pediatrics·Lee A Polikoff, E Vincent S Faustino
Nov 17, 2015·Clinical Nuclear Medicine·Patricia Cornejo, Gerald A Mandell
Jul 9, 2020·The Pediatric Infectious Disease Journal·John S BradleyMekki Bensaci
Feb 8, 2019·Journal of Pediatric Orthopedics·Michael A BenvenutiDerek J Williams
Aug 18, 2020·Journal of Inflammation Research·Anna LichotaEligia M Szewczyk
Jul 1, 2014·Journal of Pediatric Orthopedics·Nicole I Montgomery, Scott Rosenfeld
May 29, 2015·Clinical Microbiology Reviews·Steven Y C TongVance G Fowler

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