Deep venous thrombosis: The valve cusp hypoxia thesis and its incompatibility with modern orthodoxy

Medical Hypotheses
P Colm Malone, Paul S Agutter

Abstract

The valve cusp hypoxia thesis (VCHT) of the aetiology of deep venous thrombosis (DVT) was adumbrated in this journal in 1977 and fully articulated in 2008, the original hypothesis having been strongly corroborated by experiments published in 1981 and 1984. It presents a unitary account of the pathogenesis of venous thrombosis and embolism that is rooted in the pathophysiological tradition of Hunter, Virchow, Lister, Welch and Aschoff, a tradition traceable back to Harvey. In this paper we summarise the thesis in its mature form, consider its compatibility with recent advances in the DVT field, and ask why it has not yet been assimilated into the mainstream literature, which during the past half century has been dominated by a haematology-orientated 'consensus model'. We identify and discuss seven ways in which the VCHT is incompatible with these mainstream beliefs about the aetiology of venous thrombosis, drawing attention to: (1) the spurious nature of 'Virchow's triad'; (2) the crucial differences between 'venous thrombus' and 'clot'; the facts that (3) venous thrombi form in the valve pockets (VVPs), (4) DVT is not a primarily haematological condition, (5) the so-called 'thrombophilias' are not thrombogenic per se; (6) the c...Continue Reading

References

Sep 1, 1977·Medical Hypotheses·P C Malone
Jul 1, 1974·Journal of Clinical Pathology·S Sevitt
Apr 21, 1999·Lancet·F R Rosendaal
Apr 5, 2002·Journal of Vascular Surgery·Fedor LurieBo Eklof
Oct 19, 2002·Current Opinion in Critical Care·Vadim S Ten, David J Pinsky
Oct 1, 1960·Annals of Surgery·A D MCLACHLINE G RAWLING
Sep 1, 1952·Annals of Surgery·P B SAMUELS, D R WEBSTER
Feb 26, 2004·Southern Medical Journal·Daniel J BrotmanAxel C Matzdorff
Nov 24, 2005·Hematology·Frits R Rosendaal
Aug 15, 2006·QJM : Monthly Journal of the Association of Physicians·P C Malone, P S Agutter
Sep 12, 2008·British Journal of Haematology·Catherine N Bagot, Roopen Arya
Feb 14, 2009·Seminars in Thrombosis and Hemostasis·Giuseppe Lippi, Massimo Franchini
Apr 7, 2009·British Journal of Haematology·Padraic Colm Malone, Paul S Agutter
Aug 18, 2009·Blood Reviews·Charles T Esmon
Oct 3, 2009·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Houria I Hassouna
Aug 13, 2010·Theoretical Biology & Medical Modelling·David K CundiffJohn C Pezzullo
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tobias A FuchsDenisa D Wagner
Nov 3, 2010·Annual Review of Physiology·Edwin G Bovill, Albert van der Vliet
Nov 5, 2010·Clinics in Chest Medicine·Julia A M Anderson, Jeffrey I Weitz
Jul 17, 2013·Journal of Thrombosis and Haemostasis : JTH·C SchulzS Massberg
Aug 6, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sarah C ChristiaansJean Francois Pittet
Jul 19, 2014·BMJ : British Medical Journal·Peter MacCallumDavid Keeling

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Citations

Jun 24, 2017·Anesthesia and Analgesia·Ronald J Gordon, Frederick W Lombard

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