Deep white matter hyperintensities, microstructural integrity and dual task walking in older people

Brain Imaging and Behavior
Tabassom GhanavatiKim Delbaere

Abstract

To examine neural, physiological and cognitive influences on gait speed under single and dual-task conditions. Sixty-two community-dwelling older people (aged 80.0 ± 4.2 years) participated in our study. Gait speed was assessed with a timed 20-meter walk under single and dual-task (reciting alternate letters of the alphabet) conditions. Participants also underwent tests to estimate physiological fall risk based on five measures of sensorimotor function, cognitive function across five domains, brain white matter (WM) hyperintensities and WM microstructural integrity by measuring fractional anisotropy (FA). Univariate linear regression analyses showed that global physiological and cognitive measures were associated with single (β = 0.594 and β=-0.297, respectively) and dual-task gait speed (β = 0.306 and β=-0.362, respectively). Deep WMHs were associated with dual-task gait speed only (β = 0.257). Multivariate mediational analyses showed that global and executive cognition reduced the strength of the association between deep WMHs and dual-task gait speed by 27% (β = 0.188) and 44% (β = 0.145) respectively. There was a significant linear association between single-task gait speed and mean FA values of the genu (β=-0.295) and splen...Continue Reading

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Citations

Sep 17, 2019·Annals of Clinical and Translational Neurology·Sofia FinsterwalderMarco Duering
Jun 9, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maria H NilssonOskar Hansson
Mar 2, 2021·Frontiers in Neurology·Bin LiuJingping Shi
Mar 4, 2020·La Revue de médecine interne·A Garnier-CrussardP Krolak-Salmon

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