Abstract
Antiviral peptides (AVPs) have been experimentally verified to block virus into host cells, which have antiviral activity with decapeptide amide. Therefore, utilization of experimentally validated antiviral peptides is a potential alternative strategy for targeting medically important viruses. In this article, we propose a dual-channel deep neural network ensemble method for analyzing variable-length antiviral peptides. The LSTM channel can capture long-term dependencies for effectively studying original variable-length sequence data. The CONV channel can build dynamic neural network for analyzing the local evolution information. Also, our model can fine-tune the substitution matrix for specifically functional peptides. Applying it to a novel experimentally verified dataset, our AVPs predictor, DeepAVP, demonstrates state-of-the-art performance of [Formula: see text] accuracy and 0.85 MCC, which is far better than existing prediction methods for identifying antiviral peptides. Therefore, DeepAVP, web server for predicting the effective AVPs, would make significantly contributions to peptide-based antiviral research.
Citations
Nov 28, 2020·Microbial Genomics·Chao WangQuan Zou
Jan 2, 2021·Plant Molecular Biology·Mengting NiuQuan Zou
Dec 29, 2020·Bioinformatics·Zhibin LvQinghua Jiang
Feb 3, 2021·Briefings in Functional Genomics·Feifei CuiQuan Zou
Feb 5, 2021·Briefings in Bioinformatics·Nguyen Quoc Khanh LeYu-Yen Ou
Dec 10, 2020·Computational and Mathematical Methods in Medicine·Yanjuan LiXiaoyan Liu
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Xu ZhangJin Wu
Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·Zifan GuoYuming Zhao
Feb 9, 2021·Frontiers in Bioengineering and Biotechnology·Yansu WangLei Xu
Feb 9, 2021·Frontiers in Cell and Developmental Biology·Zhimin BaiZhijun Liao
Feb 20, 2021·PeerJ·Qianfei HuangLichao Zhang
Feb 26, 2021·BioMed Research International·Qian ZhaoKe Han
Mar 18, 2021·RNA Biology·Lijun DouKe Han
Apr 20, 2021·Frontiers in Genetics·Yuanyuan LvBo Gao
May 20, 2021·Proteomics·Changli FengHua Shi
Oct 2, 2021·Briefings in Bioinformatics·Balachandran ManavalanGwang Lee