DeepCEST: 9.4 T Chemical exchange saturation transfer MRI contrast predicted from 3 T data - a proof of concept study

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Moritz ZaissKlaus Scheffler

Abstract

To determine the feasibility of employing the prior knowledge of well-separated chemical exchange saturation transfer (CEST) signals in the 9.4 T Z-spectrum to separate overlapping CEST signals acquired at 3 T, using a deep learning approach trained with 3 T and 9.4 T CEST spectral data from brains of the same subjects. Highly spectrally resolved Z-spectra from the same volunteer were acquired by 3D-snapshot CEST MRI at 3 T and 9.4 T at low saturation power of B1 = 0.6 µT. The volume-registered 3 T Z-spectra-stack was then used as input data for a three layer deep neural network with the volume-registered 9.4 T fitted parameter stack as target data. An optimized neural net architecture could be found and verified in healthy volunteers. The gray-/white-matter contrast of the different CEST effects was predicted with only small deviations (Pearson R = 0.89). The 9.4 T prediction was less noisy compared to the directly measured CEST maps, although at the cost of slightly lower tissue contrast. Application to an unseen tumor patient measured at 3 T and 9.4 T revealed that tumorous tissue Z-spectra and corresponding hyper-/hypointensities of different CEST effects can also be predicted (Pearson R = 0.84). The 9.4 T CEST signals acqu...Continue Reading

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Citations

Dec 11, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Felix GlangMoritz Zaiss
Jul 1, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chenlu GuoCongbo Cai
Mar 25, 2021·NeuroImage·Alexander GermanFrederik Bernd Laun
Oct 16, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jannis HanspachFrederik B Laun
May 8, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kai HerzMoritz Zaiss
Jul 24, 2021·Current Opinion in Chemical Biology·Peter C M van ZijlLinda Knutsson

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