Deepened extinction of cocaine cues.

Drug and Alcohol Dependence
David N KearnsStanley J Weiss

Abstract

A method for reducing the power of drug cues could help in treating drug abuse and addiction. Extinction has been used, with mixed success, in such an effort. Research with non-drug cues has shown that simultaneously presenting (compounding) those cues during extinction can enhance the effectiveness of extinction. The present study investigated whether this procedure could be used to similarly deepen the extinction of cocaine cues. Rats were first trained to self-administer cocaine during tone, click, and light stimuli. Then, these stimuli were subjected to extinction in an initial phase where they were presented individually. In a second extinction phase, one of the auditory stimuli (counterbalanced) was compounded with the light. The other auditory stimulus continued to be presented alone. Rats were then given a week of rest in their homecages prior to testing for spontaneous recovery of cocaine seeking. The cue that was compounded with the light during the second phase of extinction training occasioned less spontaneous recovery of cocaine seeking than the cue that was always presented individually during extinction. Increasing the number of compound cue extinction sessions did not produce a greater deepened extinction effect...Continue Reading

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Citations

Dec 13, 2012·Experimental and Clinical Psychopharmacology·Brendan J TunstallDavid N Kearns
Sep 4, 2013·Neurobiology of Learning and Memory·Travis P ToddMark E Bouton
Feb 13, 2016·Behavioural Pharmacology·David N Kearns, Alan Silberberg
May 23, 2015·Appetite·Kerri N Boutelle, Mark E Bouton
Mar 17, 2020·Cellular and Molecular Life Sciences : CMLS·Brooke N Bender, Mary M Torregrossa
Jan 17, 2021·Neuroscience and Biobehavioral Reviews·Mihaela D IordanovaLaura H Corbit
Sep 25, 2020·Physiological Reviews·Mark E BoutonGavan P McNally
Jun 25, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rajtarun MadangopalBruce T Hope
Nov 18, 2015·Learning & Memory·Cesar A O CoelhoElizabeth A Phelps
Nov 19, 2013·Learning & Memory·Carolyn E JonesMarie-H Monfils

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