PMID: 490145Jan 1, 1979Paper

Deeper insight into HBsAg--anti-albumin antibody correlations

Journal of Medical Virology
R LenkeiI Dobre

Abstract

The presence and titers of anti-albumin antibodies (AAA)--ie, precipitins (AA-IP) and agglutinins (AA-Aggl)--and the serum concentrations of immunoglobulins and albumin were determined in 210 asymptomatic carriers of HBsAg grouped according to HBsAg titer and subtype. A different immunologic pattern was observed in the HBsAg/ad and HBsAg/ay carriers, the results suggesting an increased aggressivity for the HBsAg/ay subtype which was evident in subjects with lower HBs antigenemia and characterized by higher concentrations of IgG and IgM and rises in AA-P titers. A positive linear correlation was found between HBsAg and AA-Aggl titers; the carriage of HBsAg/ad was associated with significant higher values of AA-Aggl than of HBsAg/ay. These subtle correlations between HBsAg titer and subtype and AAA suggest that the human serum albumin (HSA) known to exist on the HBsAg particles may be similar in a modified form, to that representing AAA specificity.

References

Sep 1, 1975·The American Journal of the Medical Sciences·A NowoslawskiJ Slusarczyk
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Sep 1, 1978·Immunochemistry·D OnicăV Gheţie
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Jan 1, 1977·Journal of Immunological Methods·R Lenkei, V Ghetie
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Jan 1, 1977·Journal of Medical Virology·R LenkeiI Dobre
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Jul 1, 1974·The Journal of Clinical Investigation·S Hauptman, T B Tomasi
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans

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Citations

Aug 26, 1983·Journal of Immunological Methods·G TrioloA Rinaldi
Sep 1, 1981·Mechanisms of Ageing and Development·V GhetieI Mărgineanu
Jun 1, 1981·Infection and Immunity·S N Thung, M A Gerber

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