Deepoxy-deoxynivalenol retains some immune-modulatory properties of the parent molecule deoxynivalenol in piglets

Archives of Toxicology
Alix PierronIsabelle P Oswald

Abstract

Deoxynivalenol (DON) is the most abundant trichothecene in food and feed. It causes both acute and chronic disorders of the human and animal intestine, liver and the immune system. The structural basis for the toxicity of DON has not been fully elucidated. Using the pig as a target and a model species for human, the toxicity of DON and its deepoxy-metabolite (DOM-1) was compared. Animals were exposed by gavage to 1 and 0.5 nmol toxin/kg b.w./day for 2 and 3 weeks respectively. Whatever the dose/duration, DOM-1 was less toxic than DON in terms of weight gain and emesis. In the 3-week experiment, animals were vaccinated with ovalbumin, and their immune response was analyzed in addition to tissue morphology, biochemistry and hematology. DON impaired the morphology of the jejunum and the ileum, reduced villi height, decreased E-cadherin expression and modified the intestinal expression of cytokines. Similarly, DON induced hepatotoxicity as indicated by the lesion score and the blood biochemistry. By contrast, DOM-1 only induced minimal intestinal toxicity and did not trigger hepatotoxicity. As far as the immune response was concerned, the effects of ingesting DOM-1 were similar to those caused by DON, as measured by histopathology ...Continue Reading

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Citations

Nov 4, 2020·Journal of Applied Toxicology : JAT·Hilda M Guerrero-NetroYounes Chorfi
Nov 11, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Toa OokawaraTomoki Fukuyama
Sep 3, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lei GeKehe Huang
Dec 17, 2020·Comprehensive Reviews in Food Science and Food Safety·Hongyan GuoXiulan Sun
Mar 21, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ana Paula F L BracarenseIsabelle P Oswald
Mar 8, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Imourana Alassane-KpembiIsabelle P Oswald
Jul 5, 2021·Toxicon : Official Journal of the International Society on Toxinology·Vinicius DuarteCarlos Augusto Mallmann

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Methods Mentioned

BETA
ELISA

Software Mentioned

Anexplo
MOTIC Image Plus

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