PMID: 16649455May 3, 2006Paper

Default from tuberculosis treatment programme in Sagamu, Nigeria

Nigerian Journal of Medicine : Journal of the National Association of Resident Doctors of Nigeria
O J DanielO K Alausa

Abstract

The study was embarked on to determine the risk factors associated with default from tuberculosis treatment in Sagamu, Nigeria. A retrospective study of 774 adult patients aged 15 years and above registered for antituberculosis DOTS therapy was conducted between January 1997 and December 2003 at the Department of Community Medicine and Primary Care, Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria. Patients who defaulted (cases) during the course of treatment were compared with non-defaulters (controls) who commenced and completed their TB treatment at the same time. There were 178 (23%) defaulted cases during the study period. Defaulting rate was highest (78.1%) during the continuation phase of the treatment. There was a significant downward trend in default rate from 37.9% in 1997 to 8.4% in 2003 (p < 0.001). HIV-positive patients had twice the risk of default during the intensive phase of treatment than HIV-negative patients (OR 2.61: CI 0.84-7.97; P = 0.06). Important risk factor associated with non-compliance was male sex 9 OR 1.64: CI. 1.15-2.34; p < 0.01). HIV status (OR: 1.4 CI: 0.77-2.57; p > 0.05), previous treatment (OR: 0.75 CI: 0.43-1.30: p > 0.05), sputum smear result (1.02: CI: 0.59-1.74: p > 0.05) ...Continue Reading

Citations

Mar 1, 2012·Transactions of the Royal Society of Tropical Medicine and Hygiene·Mariana Garcia CrodaJulio Croda
Oct 12, 2010·Journal of Global Infectious Diseases·Geeta S Pardeshi
Feb 13, 2008·Tropical Medicine & International Health : TM & IH·Margaret E KrukChristine A Aguiar
May 19, 2011·Tropical Medicine & International Health : TM & IH·Sawsan ElbireerYukari C Manabe
Mar 22, 2013·Japanese Journal of Infectious Diseases·Aylin BabalikStephen A McCurdy

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