Default mode network activity in schizophrenia studied at resting state using probabilistic ICA

Schizophrenia Research
Gianluca MingoiaIgor Nenadic

Abstract

Alterations in brain function in schizophrenia and other neuropsychiatric disorders are evident not only during specific cognitive challenges, but also from functional MRI data obtained during a resting state. Here we apply probabilistic independent component analysis (pICA) to resting state fMRI series in 25 schizophrenia patients and 25 matched healthy controls. We use an automated algorithm to extract the ICA component representing the default mode network (DMN) as defined by a DMN-specific set of 14 brain regions, resulting in z-scores for each voxel of the (whole-brain) statistical map. While goodness of fit was found to be similar between the groups, the region of interest (ROI) as well as voxel-wise analysis of the DMN showed significant differences between groups. Healthy controls revealed stronger effects of pICA-derived connectivity measures in right and left dorsolateral prefrontal cortices, bilateral medial frontal cortex, left precuneus and left posterior lateral parietal cortex, while stronger effects in schizophrenia patients were found in the right amygdala, left orbitofrontal cortex, right anterior cingulate and bilateral inferior temporal cortices. In patients, we also found an inverse correlation of negative ...Continue Reading

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Citations

Jul 31, 2013·European Archives of Psychiatry and Clinical Neuroscience·Carsten M KlingnerIgor Nenadic
Nov 13, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Wenbin GuoChangqing Xiao
Jul 1, 2014·Revista colombiana de psiquiatría·Cristian VargasCarlos López-Jaramillo
Apr 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Shashwath A MedaGodfrey D Pearlson
Jul 25, 2013·Brain Structure & Function·Christoph HelmchenThomas F Münte
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May 23, 2014·IEEE Transactions on Bio-medical Engineering·Defeng WangLin Shi
Feb 5, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Wenbin GuoChangqing Xiao
Mar 10, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Wenbin GuoJingping Zhao
Aug 7, 2013·Psychiatry Research·Gianluca MingoiaIgor Nenadic
Oct 26, 2013·Neuroscience and Biobehavioral Reviews·Tianzi JiangMing Song
Jul 27, 2015·Medical Image Analysis·Bilwaj GaonkarUNKNOWN Alzheimers Disease Neuroimaging Initiative
Aug 4, 2015·Journal of Neurodevelopmental Disorders·Maria Carmela PadulaStephan Eliez
May 27, 2015·Explore : the Journal of Science and Healing·Peggy BoschSabina Lim
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Jun 4, 2013·Schizophrenia Research·François OrliacPascal Delamillieure
Jan 3, 2015·Schizophrenia Research·Christina AndreouChristoph Mulert
Mar 15, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cali F BartholomeuszStephen J Wood
Mar 13, 2015·Frontiers in Behavioral Neuroscience·Hsiao-Lan Sharon WangRongjun Yu
Apr 3, 2019·Reviews in the Neurosciences·Noemi Császár-NagyIstván Bókkon

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