Default mode network alterations during implicit emotional faces processing in first-episode, treatment-naive major depression patients

Frontiers in Psychology
Huqing ShiShuqiao Yao

Abstract

Previous studies have focused on resting-state default mode network (DMN) alterations in the development and maintenance of depression; however, only a few studies have addressed DMN changes during task-related processing and their results are inconsistent. Therefore, we explored DMN patterns in young adult patients with first-episode, treatment-naïve major depressive disorder (MDD) performing an implicit emotional processing task. Patients with MDD (N = 29) and healthy controls (N = 33) were subjected to functional magnetic resonance imaging (fMRI) at rest and while performing a gender judgment task. Group independent component analysis (ICA) was used to identify DMN component under task state for both groups. The DMN of participants with MDD had decreased functional connectivity in bilateral prefrontal areas compared to controls. Right prefrontal gyrus connectivity for MDD patients correlated negatively with scores on maladaptive scales of the Cognitive Emotion Regulation Questionnaire (CERQ). Our findings suggest that depressed people have altered DMN patterns during implicit emotional processing, which might be related to impaired internal monitoring and emotional regulation ability.

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Citations

Aug 24, 2016·NeuroImage. Clinical·Rajamannar RamasubbuRussell Greiner
Sep 1, 2016·Computational and Mathematical Methods in Medicine·César Romero-RebollarVerónica Medina-Bañuelos
Oct 23, 2016·Journal of Psychiatric Research·Huawang WuJiaojian Wang
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Mar 16, 2019·Frontiers in Psychology·Junfeng BianLiangshi Yan
Jan 1, 2018·Journal of the American Statistical Association·Ryan WarnickMarina Vannucci

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Software Mentioned

Prime
GIFT ( Group ICA of fMRI Toolbox )
AlphaSim

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