Default mode network connectivity as a function of familial and environmental risk for psychotic disorder

PloS One
S C T PeetersGenetic Risk and Outcome of Psychosis (G.R.O.U.P.)

Abstract

Research suggests that altered interregional connectivity in specific networks, such as the default mode network (DMN), is associated with cognitive and psychotic symptoms in schizophrenia. In addition, frontal and limbic connectivity alterations have been associated with trauma, drug use and urban upbringing, though these environmental exposures have never been examined in relation to DMN functional connectivity in psychotic disorder. Resting-state functional MRI scans were obtained from 73 patients with psychotic disorder, 83 non-psychotic siblings of patients with psychotic disorder and 72 healthy controls. Posterior cingulate cortex (PCC) seed-based correlation analysis was used to estimate functional connectivity within the DMN. DMN functional connectivity was examined in relation to group (familial risk), group × environmental exposure (to cannabis, developmental trauma and urbanicity) and symptomatology. There was a significant association between group and PCC connectivity with the inferior parietal lobule (IPL), the precuneus (PCu) and the medial prefrontal cortex (MPFC). Compared to controls, patients and siblings had increased PCC connectivity with the IPL, PCu and MPFC. In the IPL and PCu, the functional connectivit...Continue Reading

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Citations

Dec 1, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Oscar Martin-SantiagoVicente Molina
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Mar 2, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zhuo-Ya YangRaymond C K Chan

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Software Mentioned

BrainVoyager QX
XTREG
STATA MARGINS
Analysis of Functional NeuroImages ( AFNI
Matlab
MPRAGE
MDEFT
Oxford Centre for Functional MRI of the Brain Software Library...
STATA
NeuroElf

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