PMID: 9548721May 23, 1998Paper

Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice

The Journal of Cell Biology
Y YonekawaN Hirokawa

Abstract

The nerve axon is a good model system for studying the molecular mechanism of organelle transport in cells. Recently, the new kinesin superfamily proteins (KIFs) have been identified as candidate motor proteins involved in organelle transport. Among them KIF1A, a murine homologue of unc-104 gene of Caenorhabditis elegans, is a unique monomeric neuron- specific microtubule plus end-directed motor and has been proposed as a transporter of synaptic vesicle precursors (Okada, Y., H. Yamazaki, Y. Sekine-Aizawa, and N. Hirokawa. 1995. Cell. 81:769-780). To elucidate the function of KIF1A in vivo, we disrupted the KIF1A gene in mice. KIF1A mutants died mostly within a day after birth showing motor and sensory disturbances. In the nervous systems of these mutants, the transport of synaptic vesicle precursors showed a specific and significant decrease. Consequently, synaptic vesicle density decreased dramatically, and clusters of clear small vesicles accumulated in the cell bodies. Furthermore, marked neuronal degeneration and death occurred both in KIF1A mutant mice and in cultures of mutant neurons. The neuronal death in cultures was blocked by coculture with wild-type neurons or exposure to a low concentration of glutamate. These res...Continue Reading

References

Dec 11, 1992·Trends in Neurosciences·J L Franklin, E M Johnson
Dec 1, 1992·The Journal of Cell Biology·H AizawaN Hirokawa
Jul 1, 1991·The Journal of Cell Biology·N HirokawaS T Brady
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S A Lipton
Oct 1, 1980·Physiological Reviews·B Grafstein, D S Forman
Jun 1, 1994·The Journal of Cell Biology·S KondoN Hirokawa
Jun 9, 1994·Nature·M GeppertT C Südhof
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·A V GudkovI B Roninson
Aug 1, 1993·Current Opinion in Cell Biology·R Bauerfeind, W B Huttner
Oct 1, 1993·Current Opinion in Neurobiology·N Hirokawa
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·H T McMahonT C Südhof
Jan 1, 1990·The European Journal of Neuroscience·Kikuya Kato
Apr 1, 1996·Trends in Cell Biology·N Hirokawa

❮ Previous
Next ❯

Citations

Jun 16, 2012·The Cerebellum·Roberto Di FabioCarlo Casali
May 5, 2005·Experimental Neurology·Roger S ChungJames C Vickers
Jun 30, 2000·Current Opinion in Cell Biology·S P Koushika, M L Nonet
Feb 13, 2001·Current Opinion in Cell Biology·W R Schief, J Howard
Feb 19, 2000·Current Opinion in Cell Biology·S L Rogers, V I Gelfand
Feb 17, 2001·Current Opinion in Neurobiology·A M Schaefer, M L Nonet
Feb 21, 2013·ACS Chemical Neuroscience·Allyson E SgroDaniel T Chiu
Sep 24, 2009·Nature Reviews. Molecular Cell Biology·Nobutaka HirokawaShinsuke Niwa
Nov 26, 2009·Nature Reviews. Molecular Cell Biology·Nobutaka HirokawaYasushi Okada
Feb 16, 2005·Nature Reviews. Neuroscience·Nobutaka Hirokawa, Reiko Takemura
Oct 16, 2004·Molecular Biology of the Cell·Florian Fuchs, Benedikt Westermann
Mar 9, 2012·Molecular Biology of the Cell·Gerald F ReisLawrence S B Goldstein
Aug 4, 2001·Molecular and Cellular Biology·T Plitz, K Pfeffer
Dec 28, 1999·Annual Review of Cell and Developmental Biology·L S Goldstein, A V Philp
Dec 28, 1999·Annual Review of Cell and Developmental Biology·S S Brown
Jun 9, 2000·Annual Review of Neuroscience·L S Goldstein, Z Yang
Apr 10, 2007·Annual Review of Neuroscience·A Kimberley McAllister
Nov 5, 2002·Annual Review of Pharmacology and Toxicology·Richard Nass, Randy D Blakely
Apr 17, 2008·Cancer Research·Mohammad Obaidul HoqueDavid Sidransky
Dec 3, 2003·BMC Genomics·Martin Kollmar, Gernot Glöckner
Nov 25, 2005·Journal of Cell Science·Peter J Hollenbeck, William M Saxton
Oct 3, 2006·PLoS Genetics·Jason E Duncan, Lawrence S B Goldstein
Jun 19, 2013·PloS One·Filipa I BaptistaAntónio F Ambrósio
Jun 1, 2014·PloS One·Gary J IacobucciShermali Gunawardena
Aug 10, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christoph MaasCraig C Garner
Aug 27, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yujiro Shidara, Peter J Hollenbeck
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·H MikiN Hirokawa
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Koji IkegamiMitsutoshi Setou
Jul 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jeremy S Dittman, Joshua M Kaplan
May 9, 2014·Journal of Medical Genetics·Marjolein H WillemsenTjitske Kleefstra
Oct 20, 2012·Journal of Molecular Neuroscience : MN·Sara L C EstevesEdgar F da Cruz e Silva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.