PMID: 9438208Jan 23, 1998Paper

Defect in Th1-like cells of nonresponders to hepatitis B vaccine

Human Immunology
M G ChedidE J Yunis

Abstract

Peripheral blood lymphocytes from nonresponders to hepatitis B vaccine (HBsAg) failed to undergo a proliferative response to recombinant HBsAg in vitro, whereas cells from responders proliferated vigorously. The lack of proliferative response was not due to defective antigen presentation in that MHC-identical responder and nonresponder antigen presenting cells were equally effective in stimulating responder T cells. Nonresponder T cells did not proliferate in response to antigen-pulsed MHC identical responder antigen presenting cells. The present study demonstrated that: 1) there were no detectable (1 in < 20 x 10(4) HBsAg-precursor T cells in any of the nonresponders, while in responders the frequency of HBsAg-precursor T cells ranged from 1 in 3.2 x 10(3) to 1 in 40 x 10(3); 2) nonresponder cell cultures did not secrete IL-2 in response to HBsAg stimulation; 3) exogenous recombinant IL-2 did not restore the proliferative response of the T cells in HBsAg-pulsed cultures of nonresponders. These results suggest that the cellular basis for the lack of response to HBsAg is a defect in HBsAg-specific Th1-like cells; either there is an absence of the Th1 cells or cells with TCR specificity for HBsAg are present but are unresponsive ...Continue Reading

References

Jan 1, 1978·International Archives of Allergy and Applied Immunology·R N CahillZ Trnka
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Apr 1, 1992·Current Opinion in Immunology·B ArnoldG J Hämmerling
Jul 1, 1992·European Journal of Immunology·G SchönrichB Arnold
Feb 1, 1992·The Journal of Experimental Medicine·M S KruskallD Marcus-Bagley
Mar 1, 1992·Research in Immunology·J F Miller, W R Heath
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G MorahanJ F Miller
Mar 1, 1991·The Journal of Experimental Medicine·E EgeaE J Yunis
Mar 8, 1991·Science·B Rocha, H von Boehmer
Jun 15, 1990·Science·H von Boehmer, P Kisielow
Jan 1, 1991·The Journal of Experimental Medicine·M J DallmanP J Morris
Aug 1, 1990·Immunology Today·C E SharrockS Man
Oct 1, 1990·The Journal of Experimental Medicine·B L RellahanL A Matis
Sep 14, 1989·The New England Journal of Medicine·C A AlperE J Yunis
Aug 1, 1988·Immunological Reviews·H R MacDonaldD H Raulet
Apr 23, 1993·Cell·H von Boehmer, P Kisielow
Jan 1, 1993·Annual Review of Immunology·P S Linsley, J A Ledbetter
Apr 1, 1993·The Journal of Experimental Medicine·A Bonomo, P Matzinger
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·C C Goodnow
Jun 15, 1997·The Journal of Clinical Investigation·S RossolN V Naoumov

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Citations

Apr 20, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Eki EdwardsCharlotte Cunningham-Rundles
May 24, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M A AvanziniR Maccario
Nov 11, 2003·Clinical and Diagnostic Laboratory Immunology·Patricia AguilarAnne Kennel De March
Apr 30, 2008·World Journal of Gastroenterology : WJG·Martin R WeihrauchJoachim L Schultze
Jun 21, 2008·World Journal of Gastroenterology : WJG·Vijayakumar VeluSadras-Panchatcharam Thyagarajan
Aug 10, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·B AlbarranL Berrueta
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chengbin WangRichard A Kaslow
Nov 8, 2005·The American Journal of Medicine·Jeffrey C Laurence
Jun 7, 2005·Advanced Drug Delivery Reviews·Hansi J DeanConnie Schmaljohn
Jul 16, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jinxian PeiYongsheng Yu
Apr 27, 2010·Journal of Medical Virology·Luciana Conci MacedoRicardo Alberto Moliterno
Jun 4, 2004·Expert Opinion on Biological Therapy·Joel R Haynes
Feb 14, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R OrlandoG Tosone
Apr 11, 2013·Human Vaccines & Immunotherapeutics·Carina RosenbergEskild Petersen
Jan 18, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sylvia M KiertscherMichael D Roth
Oct 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ho-Yuan ChouMi-Hua Tao
Oct 31, 2014·World Journal of Gastroenterology : WJG·Hsin-Yun SunChien-Ching Hung
Nov 4, 2015·World Journal of Gastroenterology : WJG·Alicia C MarínMaría Chaparro
Aug 10, 2019·Molecular Pharmaceutics·Xiang Yi ChenMohd Cairul Iqbal Mohd Amin

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