Defect induced asymmetric pit formation on hydroxyapatite

Langmuir : the ACS Journal of Surfaces and Colloids
Ki-Young KwonSeung-Wuk Lee

Abstract

Defect sites on bone minerals play a critical role in bone remodeling processes. We investigated single crystal hydroxyapatite (100) surfaces bearing crystal defects under acidic dissolution conditions using real-time in situ atomic force microscopy. At defect sites, surface structure-dependent asymmetric hexagonal etch pits were formed, which dominated the overall dissolution rate. Meanwhile, dissolution from the flat terraces proceeded by stochastic formation of flat bottom etch pits. The resulting pit shapes were intrinsically dictated by the HAP crystal structure. Computational modeling also predicted different step energies associated with different facets of the asymmetric etch pits. Our microscopic observations of HAP dissolution are significant for understanding the effects of local surface structure on the bone mineral remodeling process and provide useful insights for the design of novel therapies for treating osteoporosis and dental caries.

References

Dec 14, 1977·Calcified Tissue Research·J C Voegel, R M Frank
Aug 1, 1989·Calcified Tissue International·G DaculsiD Mitre
Apr 1, 1988·Experimental Cell Research·I A SilverD J Etherington
Jan 4, 1974·Nature·E C MorenoR T Zahradnik
Oct 1, 1966·Nature·B H BradyB M Smythe
Sep 1, 2000·Science·S L Teitelbaum
Sep 1, 2000·Science·G A Rodan, T J Martin
Jun 8, 2001·Journal of the American Chemical Society·R TangC A Orme
Dec 14, 2002·Science·Renald SchaubFlemming Besenbacher
Dec 12, 1964·Nature·M I KAYA S POSNER
Feb 27, 2004·Journal of Biomedical Materials Research. Part a·A R El-GhannamR J Composto
Oct 30, 2004·The Journal of Chemical Physics·Rune KristensenKeith Refson
Jun 30, 2005·Journal of the American Chemical Society·James M GibsonGary P Drobny
Oct 26, 2005·Physical Review Letters·Ki-Young KwonTalat S Rahman
Apr 3, 2007·Journal of the American Chemical Society·Lisa A CapriottiJoel P Schneider
Jun 2, 1978·Science·M B Tomson, G H Nancollas
Jan 1, 1996·Journal of the American Chemical Society·Eric S EberhardtRonald T Raines

❮ Previous
Next ❯

Citations

Jul 19, 2012·Journal of Materials Science. Materials in Medicine·Esther García-TuñónFrancisco Guitián
Feb 5, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Woo-Jae ChungSeung-Wuk Lee
Apr 5, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Ki-Young KwonSeung-Wuk Lee
Sep 21, 2012·Acta Crystallographica. Section B, Structural Science·Esther García-TuñónFrancisco Guitián
Oct 28, 2016·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·José Reyes-GasgaEtienne F Brès
Feb 26, 2012·World Journal of Methodology·Sergey V Dorozhkin
Jun 6, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Ki-Young KwonSeung-Wuk Lee
Aug 14, 2017·ACS Biomaterials Science & Engineering·Thomas FaidtFrank Müller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Langmuir : the ACS Journal of Surfaces and Colloids
Ki-Young KwonSeung-Wuk Lee
Journal of Physics. Condensed Matter : an Institute of Physics Journal
Qingyan WangQikun Xue
Environmental Science & Technology
José Manuel AstillerosLurdes Fernández-Díaz
© 2022 Meta ULC. All rights reserved