PMID: 2119952Oct 1, 1990Paper

Defective cytostatic activity of pulmonary alveolar macrophages in primary lung cancer

Chest
C F McDonald, R C Atkins

Abstract

Macrophages are thought to play an important immune effector cell role in antitumor host defense. It remains unclear whether PAM antitumor activity in patients with lung cancer is normal or impaired. We examined PAM cytostasis in patients with lung cancer and in control subjects and determined whether the in vitro PAM response could be enhanced by gamma-interferon. Nineteen patients with primary lung carcinoma and 15 control patients underwent BAL. Five patients with cancer underwent lavage of both lungs to assess whether any abnormality found related to tumor proximity or was part of a more generalized defect. Cytostatic activity was assessed by measuring inhibition of incorporation of tritiated thymidine into the target cell U937. There was a significant difference in baseline cytostatic activity between patients with cancer (mean +/- SE, 59 +/- 7 percent) and control patients (92 +/- 2 percent) (p less than 0.0002). The increase in cytostatic function after stimulation with gamma-interferon (1,250 units/ml) was higher in the group with cancer (28 +/- 5 percent increase from baseline) than in controls (5 +/- 1 percent) (p less than 0.0005). Cytostasis after stimulation was not significantly different between the groups. In th...Continue Reading

References

Oct 1, 1977·The Annals of Thoracic Surgery·C F Mountain
Jun 1, 1977·Journal of Clinical Pathology·I LauderR Sainsbury
Jul 1, 1987·Chest·P KratikanontY Chapman
Sep 11, 1980·The New England Journal of Medicine·C F NathanZ A Cohn
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Apr 1, 1985·Immunology Today·G Trinchieri, B Perussia

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Citations

Mar 18, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M DabrowskaR Chazan
Apr 1, 1993·Mayo Clinic Proceedings·R J Pisani
Dec 17, 2008·The Lancet Oncology·Sandro VentoZelalem Temesgen
Apr 17, 1999·Clinics in Chest Medicine·R P Baughman, E M Pina
Oct 30, 1999·Respiratory Medicine·H YanagawaS Sone
Jan 18, 2006·Clinical and Experimental Immunology·D S PouniotisC F McDonald
Jan 1, 2014·Lung Cancer International·Saleh A AlmatroodiDodie S Pouniotis

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