Defective enamel ultrastructure in diabetic rodents

International Journal of Paediatric Dentistry
M AtarU M Spornitz

Abstract

We investigated six different types of diabetic rodents. Four expressed a genetic obesity resulting in diabetes. One developed diabetes induced by a diet-dependent obesity, and one with genetic diabetes received anti-diabetic medication. The tooth samples were examined under a scanning electron microscope and with an energy dispersive microanalysis (EDX). The electron micrographs showed severe, varying degrees of damage within the six different diabetic animal types, such as irregular crystallite deposition and prism perforations in genetically obese animals compared to less-disordered prism structures in diet-dependent obesity. Anti-diabetic medication resulted in normal enamel ultrastructure. The EDX analysis revealed a reduction in the amount of calcium and phosphorus in all regions affected by diabetes. Based on these animal studies, we suggest that both juvenile diabetes type I (in infants) and adult diabetes type II (in pregnant mothers, affecting the developing foetus) may affect the normal development of teeth in humans.

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Citations

Dec 14, 2007·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·M AtarF S L Wong
Mar 11, 2008·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·M AtarP D Polly
Dec 17, 2009·Journal of Dentistry·Michael Atar, Egbert J Körperich
Apr 29, 2006·International Journal of Paediatric Dentistry·M AtarD O'Donnell
Feb 15, 2015·Journal of Dentistry·M A AbbassyT Ono
Mar 28, 2012·Laboratory Investigation; a Journal of Technical Methods and Pathology·Chih-Ko YehSherry Abboud-Werner
Dec 16, 2017·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Bruna Larissa Lago SilvaAlexandre Ribeiro do Espírito Santo

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