Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects

The New England Journal of Medicine
T J LawleyM M Frank

Abstract

Dermatitis herpetiformis is associated with the HLA-B8/DRw3 haplotype in over 90 per cent of patients, and various percentages have been reported to have circulating immune complexes. Since removal of immune complexes from the circulation is thought to depend on the Fc-receptor function of tissue macrophages, we studied this function by measuring the clearance of IgG-sensitized autologous erythrocytes in 16 patients with dermatitis herpetiformis, in normal controls with the HLA-B8/DRw3 haplotype, and in randomly selected controls. All patients were HLA-B8 positive, and all of 12 patients tested were HLA-DRw3 positive. Erythrocyte clearance was reduced in eight of the 16 patients, but did not correlate with immune-complex levels. Four of eight controls with HLA-B8/DRw3 also had delayed Fc-receptor-mediated clearance as compared with normal controls. In addition, both patients and HLA-B8/DRw3-positive controls had decreased percentages and total numbers of T cells bearing Fc receptors for IgG. These findings indicate a functional Fc-receptor defect associated with the HLA-B8/DRw3 antigens.

References

Jan 1, 1976·The Journal of Clinical Investigation·A N TheofilopoulosF J Dixon
Oct 1, 1977·Kidney International·A J WoodroffeC B Wilson
Feb 1, 1978·The Journal of Investigative Dermatology·S I Katz, W Strober
Oct 1, 1979·Annals of Internal Medicine·M I HamburgerM M Frank
Mar 8, 1979·The New England Journal of Medicine·M M FrankP H Plotz
Jan 1, 1974·The Journal of Clinical Investigation·A S Fauci, D C Dale
May 20, 1972·British Medical Journal·J E PettitL Fry
Jan 1, 1981·Annual Review of Genetics·L P RyderJ Dausset

❮ Previous
Next ❯

Citations

Jan 1, 1989·Immunogenetics·H O GrundyR V Lebo
Jan 1, 1984·Archives of Dermatological Research·M KiefferJ N Blackwell
Jan 1, 1982·Rheumatology International·T J CunninghamK D Muirden
Jan 1, 1984·Rheumatology International·L Schrieber, R Penny
Apr 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J S Cameron
Sep 1, 1993·Journal of Clinical Immunology·Y OrhanS Molvalilar
Jan 1, 1994·Journal of Clinical Immunology·C T LinJ C Unkeless
Jan 1, 1986·Springer Seminars in Immunopathology·M H Wener, M Mannik
Jan 1, 1988·International Urology and Nephrology·A BranellecG Lagrue
Jan 1, 1984·Folia Microbiologica·L Fornůsek, V Vĕtvicka
Mar 1, 1986·The American Journal of Medicine·J D Heironimus, E L Perry
Jan 1, 1984·Disease-a-month : DM·J Laurence
Dec 17, 1982·Journal of Immunological Methods·K B ElkonG R Hughes
Apr 6, 1988·Journal of Immunological Methods·J W Van der MeerP C Leijh
Jun 1, 1982·Mechanisms of Ageing and Development·T OckhuizenC G Hames
Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
Apr 20, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Eki EdwardsCharlotte Cunningham-Rundles
Mar 23, 2004·Journal of Dermatological Science·Sarolta Kárpáti
May 23, 2003·Gastroenterology·Irwin M Braverman
Jul 23, 1983·Lancet
Jun 1, 1996·Journal of Hepatology·R MannaG Gasbarrini
May 10, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Peter K Gregersen
Jun 11, 1981·The New England Journal of Medicine·G F Cahill, H O McDevitt
Aug 6, 1981·The New England Journal of Medicine·S R Bartolotti
Oct 18, 1984·The New England Journal of Medicine·Y Shoenfeld, R S Schwartz
Nov 29, 1984·The New England Journal of Medicine·T J LawleyM M Frank
Sep 5, 1985·The New England Journal of Medicine·J G Kelton
Jan 23, 1986·The New England Journal of Medicine·R P KimberlyA Gibofsky
Feb 26, 1987·The New England Journal of Medicine·A D SchreiberD B Cines
Sep 14, 1989·The New England Journal of Medicine·C A AlperE J Yunis
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G A PeltzK W Moore
Sep 1, 1982·The Journal of Experimental Medicine·C C McCombs, J P Michalski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.