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Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis

Cell Research

Feb 1, 2013

Shu-Yi ChenTing Xie

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Abstract

The optic fissure (OF) is a transient opening on the ventral side of the developing vertebrate eye that closes before nearly all retinal progenitor cell differentiation has occurred. Failure to close the OF results in coloboma, a congenital disease that is a major cause of childhood bli...read more

Mentioned in this Paper

Mutant
Vertebrates
Fibroblast Growth Factor Soluble Receptor 1
FGFR1 gene
Morphogenesis
Structure of Optic Cup
Signal Transduction
FGFR1 wt Allele
MRNA Differential Display
Colony-forming Unit
Paper Details
References
  • References82
  • Citations7
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Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis

Cell Research

Feb 1, 2013

Shu-Yi ChenTing Xie

PMID: 23147794

DOI: 10.1038/cr.2012.150

Abstract

The optic fissure (OF) is a transient opening on the ventral side of the developing vertebrate eye that closes before nearly all retinal progenitor cell differentiation has occurred. Failure to close the OF results in coloboma, a congenital disease that is a major cause of childhood bli...read more

Mentioned in this Paper

Mutant
Vertebrates
Fibroblast Growth Factor Soluble Receptor 1
FGFR1 gene
Morphogenesis

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Paper Details
References
  • References82
  • Citations7
12345...

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