PMID: 7545097Sep 1, 1995Paper

Defective functional response to membrane stimuli in lymphocytes from patients with benign prostatic hyperplasia

Clinical and Experimental Immunology
M Pérez-BlasM Alvarez-Mon

Abstract

Benign prostatic hyperplasia (BPH) is a local disturbance in the prostate that may involve an inflammatory infiltrate predominantly composed of activated lymphocytes and macrophages. The activation and proliferative response of T lymphocytes to different mitogenic signals has been analysed in peripheral blood mononuclear cells (PBMC) from 45 patients with BPH and 55 healthy controls. The PBMC obtained from the patients showed a significant specific impairment in proliferation, CD25 expression and IL-2 production in response to stimulation with lectins (phytohaemagglutinin (PHA), concanavalin A (Con A)), that was not corrected by the addition of IL-2 or of phorbol esters (phorbol myristate acetate (PMA)). Also, the CD28 response was defective in patient PBMC. Activation with anti-CD3 or anti-CD2 MoAbs was normal, but the addition of PMA to these stimuli provoked a significant defective response. Only the use of transmembrane stimuli (PMA and ionomycin) elicited responses similar to those found in the control group. The results indicate that peripheral T lymphocytes from BPH patients show a functional impairment that is mainly explained by an alteration of membrane signals (PHA, CD28) and is distal to protein kinase C (PKC) activ...Continue Reading

References

Jul 1, 1992·Clinical and Experimental Immunology·M Pérez-BlasA Arnaiz-Villena
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C D GimmiL M Nadler
Jun 1, 1990·Immunology Today·C H JuneC B Thompson
Nov 1, 1989·Scandinavian Journal of Immunology·A BertottoR Vaccaro
Jun 1, 1993·Current Opinion in Immunology·M K Jenkins, J G Johnson
Feb 1, 1995·Gut·J A VargasA Durántez
May 1, 1994·Clinical and Experimental Immunology·S ZielenS C Meuer
Jun 1, 1993·Cellular Immunology·P HöllsbergD A Hafler

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Citations

Mar 16, 2006·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Haiwen ChenGo Kimura
Jul 13, 2007·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Narumi TsuboiYu Fukuda
Nov 26, 2015·Clinical Investigation·Kouji IzumiChawnshang Chang
Dec 22, 2006·European Urology·Gero KramerMichael Marberger

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