Defective histone H3K27 trimethylation modification in embryos derived from heated mouse sperm

Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
Shibin ChaoGuolan Gao

Abstract

The mouse sperm genome is resistant to in vitro heat treatment, and embryos derived from heated sperm can support full-term embryonic development, but the blastocyst rate and implantation rate are lower compared to embryos derived from fresh sperm. In the present study, the patterns of DNA methylation, histone H4K12 (ACH4K12) acetylation, H3K9 trimethylation (H3K9-TriM), and H3K27 trimethylation (H3K27-TriM) in preimplantation embryos derived from 65 °C-heated sperm were investigated. Although no evident changes in global DNA methylation, histone H4K12 (ACH4K12) acetylation, and H3K9 trimethylation (H3K9-TriM) were found, significantly lower levels of H3K27-TriM, which was thought to be one of the reasons for low efficiency of mouse cloning, were found in the inner cell mass of heated-sperm derived blastocysts. Thus, defective modification of H3K27-TriM might contribute to compromised development of embryos derived from heated sperm.

References

Mar 1, 1991·Biology of Reproduction·K YanagidaR G Kleinfeld
Aug 1, 1987·Journal of the Royal Society of Medicine·M J Ball
Apr 1, 1995·Biology of Reproduction·Y Kimura, R Yanagimachi
Jul 14, 1998·Nature Biotechnology·T Wakayama, R Yanagimachi
Feb 17, 2000·Nature·W MayerT Haaf
Aug 11, 2001·Science·P A Jones, D Takai
Oct 24, 2001·Biology of Reproduction·J CozziJ P Wolf
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·W DeanW Reik
Jan 11, 2002·Developmental Biology·Fátima SantosWendy Dean
Jun 18, 2002·Current Opinion in Cell Biology·Monika Lachner, Thomas Jenuwein
Jun 25, 2004·Biology of Reproduction·Tom P FlemingJudith J Eckert
Sep 24, 2004·BMC Developmental Biology·Konstantin Lepikhov, Jörn Walter
Mar 31, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Stephen BanksPhilippa T K Saunders
Apr 6, 2005·Human Molecular Genetics·Hugh D MorganWolf Reik
Feb 27, 2007·Cell·Tony Kouzarides
Feb 27, 2007·Cell·M Azim SuraniPetra Hajkova
Mar 8, 2007·Nature Reviews. Molecular Cell Biology·Robert J Klose, Yi Zhang
Apr 5, 2007·Nature Protocols·Naoko Yoshida, Anthony C F Perry
Mar 7, 2008·Nature·Raphaël MétivierGilles Salbert
Apr 9, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Catriona PaulPhilippa T K Saunders
Feb 19, 2009·Zygote : the Biology of Gametes and Early Embryos·Hiroyuki YazawaAkira Sato
Mar 3, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Chong LiTeruhiko Wakayama
Apr 21, 2009·The International Journal of Developmental Biology·Robert Feil
Jul 16, 2009·The Journal of Biological Chemistry·Miao ZhangShaorong Gao
Sep 18, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·David MillerDavid Iles
Oct 30, 2010·Science·Suhua FengWolf Reik
Apr 15, 2011·Biology of Reproduction·Ryuzo Yanagimachi
Feb 9, 2012·Human Reproduction·Shi-Bin ChaoQing-Yuan Sun

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Citations

Jun 3, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Chelsea MarchoJesse Mager
Aug 17, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Yanina S Bogliotti, Pablo J Ross
Nov 7, 2016·Molecular Neurobiology·Zhongcheng WangXiaohua He

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