Defective induction of antigen-reactive proliferating T cells in B cell-deprived mice. II. Anti-mu treatment affects the initiation and recruitment of T cells

European Journal of Immunology
Y RonS Segal

Abstract

Mice injected from day of birth onwards with rabbit anti-mouse IgM (antim-mu) antibodies were found to be B cell-deficient and defective for the induction of antigen-reactive proliferating T cells (TPRLF). This defective induction was not due to the absence of circulating antigen-specific antibodies since the daily injections of such antibodies during exposure to antigen did not restore the ability of anti-IgM treated animals to generate TPRLF. Analyzing the cellular events implicated in the induction of virgin antigen-reactive T cells, anti-mu-treated mice manifested impairment of the three interacting cell types involved in the induction of TPRLF. Thus, peritoneal and splenic antigen-presenting cells from such animals were impaired in their capacity to signal a primary antigen-specific T cell reaction. Their splenic lymphocytes could not function as initiator cells in transferring immunogenic signals to recruit TPRLF in normal recipients. Potent antigen-specific splenic initiator cells failed to induce the recruitment of specific TPRLF in anti-mu-treated mice. The defective induction of TPRLF in anti-mu-treated mice may be due to a functional impairment of cells expressing membrane-bound IgM molecules which seemingly play a c...Continue Reading

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Citations

Sep 1, 1989·Journal of Reproductive Immunology·D W DresserJ Carter
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·P A Bretscher
May 1, 1994·The Journal of Experimental Medicine·W Y HoM M Davis
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Jul 22, 2017·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ben Shillitoe, Andrew Gennery
Apr 19, 2020·Immunological Reviews·Zhaolin Hua, Baidong Hou
Feb 13, 1996·Annals of the New York Academy of Sciences·A Khoruts, M K Jenkins
Jan 29, 2019·Frontiers in Immunology·Yi YangJean M H van den Elsen
Dec 24, 1998·Infection and Immunity·D R Brown, S L Reiner
Aug 18, 2009·Cancer Treatment Reviews·Voravit RatanatharathornJoseph P Uberti

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