Defective inhibition and inter-regional phase synchronization in pianists with musician's dystonia: an EEG study.

Human Brain Mapping
María Herrojo RuizEckart Altenmüller

Abstract

Recent neurophysiological studies have associated focal-task specific dystonia (FTSD) with impaired inhibitory function. However, it remains unknown whether FTSD also affects the inhibition (INH) of long-term overlearned motor programs. Consequently, we investigated in a Go/NoGo paradigm the neural correlates associated with the activation (ACT) and inhibition of long-term overlearned motor memory traces in pianists with musician's dystonia (MD), a form of FTSD, during a relevant motor task under constraint timing conditions with multichannel EEG. In NoGo trials, the movement related cortical potentials showed a positive shift after the NoGo signal related to inhibition and was significantly smaller over sensorimotor areas in musicians with MD. Further, we observed an increase at 850-900 ms in the power of beta oscillations which was significantly weaker for the patient group. The role of the inter-electrode phase coupling in the sensorimotor integration of inhibitory processes turned out to be the most relevant physiological marker: the global phase synchronization during INH exhibited an increase between 230 and 330 ms and 7-8 Hz, increase which was significantly smaller for pianists with MD. This effect was due to a weaker p...Continue Reading

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Citations

Jul 16, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E Altenmüller, H-C Jabusch
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Jul 14, 2018·Neural Plasticity·Sonia BettiLuisa Sartori

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