PMID: 9851930Dec 16, 1998Paper

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene

Science
A PoltorakB Beutler

Abstract

Mutations of the gene Lps selectively impede lipopolysaccharide (LPS) signal transduction in C3H/HeJ and C57BL/10ScCr mice, rendering them resistant to endotoxin yet highly susceptible to Gram-negative infection. The codominant Lpsd allele of C3H/HeJ mice was shown to correspond to a missense mutation in the third exon of the Toll-like receptor-4 gene (Tlr4), predicted to replace proline with histidine at position 712 of the polypeptide chain. C57BL/10ScCr mice are homozygous for a null mutation of Tlr4. Thus, the mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane. Destructive mutations of Tlr4 predispose to the development of Gram-negative sepsis, leaving most aspects of immune function intact.

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Jun 22, 2011·The Journal of Biological Chemistry·Cornelis van 't VeerTom van der Poll
May 6, 2011·The Journal of Biological Chemistry·Gabriela Panter, Roman Jerala
Jul 7, 2011·The Journal of Biological Chemistry·Silvia Guntermann, Edan Foley
Sep 21, 2011·The Journal of Biological Chemistry·Maninjay K AtianandJonathan A Harton
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Apr 26, 2012·The Journal of Biological Chemistry·Shuang WuZihai Li
Oct 12, 2012·The Journal of Biological Chemistry·Umeharu OhtoToshiyuki Shimizu
Jul 19, 2003·The Journal of Biological Chemistry·Mark J KarbarzChristian R H Raetz
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Feb 10, 2006·The Journal of Biological Chemistry·Xiaoyuan WangChristian R H Raetz
May 18, 2006·The Journal of Biological Chemistry·C Michael ReynoldsM Stephen Trent
Mar 30, 2007·The Journal of Biological Chemistry·Andrei E MedvedevStefanie N Vogel
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Mar 27, 2009·The Journal of Biological Chemistry·Nusa ResmanRoman Jerala
Jan 31, 2002·Mediators of Inflammation·O Michel
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Jun 8, 1999·The Journal of Experimental Medicine·R ShimazuMasao Kimoto
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Apr 19, 2000·The Journal of Experimental Medicine·S D WrightY S Chao
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Oct 23, 2002·The Journal of Experimental Medicine·Andreas SingJürgen Heesemann
Oct 23, 2002·The Journal of Experimental Medicine·Elizabeth Kopp, R Medzhitov
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Oct 22, 2003·The Journal of Experimental Medicine·Mathias W HornefStaffan Normark
Nov 19, 2003·The Journal of Experimental Medicine·Arihiro KanoXin-Yuan Fu
Oct 1, 2003·The Journal of Experimental Medicine·Katherine A FitzgeraldDouglas Golenbock
May 24, 2006·The Journal of Experimental Medicine·Annalisa MacagnoFederica Sallusto
Jul 19, 2006·The Journal of Experimental Medicine·Kinga A PowersOri D Rotstein
May 2, 2007·The Journal of Experimental Medicine·Tae Whan KimXiaoxia Li
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Aug 2, 2012·The Journal of Experimental Medicine·Melina HermanJean-Laurent Casanova
Dec 13, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M G NeteaJ W Van der Meer
Feb 15, 2001·The Journal of Infectious Diseases·B FrendéusC Svanborg
Feb 28, 2002·The Journal of Infectious Diseases·Edward J Wing, Stephen H Gregory
Jun 7, 2003·The Journal of Infectious Diseases·Richard J Ulevitch
Jun 7, 2003·The Journal of Infectious Diseases·Alan Aderem
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Nov 17, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bart Jan KullbergMihai G Netea
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Oct 21, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ian SabroeMoira K B Whyte
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Oct 29, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J M Daun, Matthew Fenton
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Aug 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·C G Romball, W O Weigle
Nov 25, 2000·Journal of Hematotherapy & Stem Cell Research·P M WongS W Chung
Jun 14, 2003·Vector Borne and Zoonotic Diseases·Venetta Thomas, Erol Fikrig
May 23, 2012·Antioxidants & Redox Signaling·Samuel LeeRichard T Lee
Aug 24, 2005·Cancer Biotherapy & Radiopharmaceuticals·Takashi KojimaRyuichiro Sasanabe
Jan 6, 2007·Hybridoma·Suganya ViriyakosolTheo N Kirkland
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