PMID: 3498788Oct 1, 1987

Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer

The Journal of Experimental Medicine
K L KomschliesIrving Goldschneider


Bone marrow prothymocytes from me/me and mev/mev mutant mice fail to generate thymocytes in irradiated (600 rad) +/+ wild-type recipients after intravenous injection. However, these same prothymocytes readily generate thymocytes after intrathymic injection. The results of the present study demonstrate that this apparent defect in the thymus-homing capacity of mev/mev prothymocytes can be corrected by mixing irradiated wild-type bone marrow cells with mev/mev bone marrow cells before intravenous injection. However, this defect is not corrected by passage of mev/mev bone marrow cells through the bone marrow of irradiated wild-type recipients. One interpretation of these results is that the maturation of prothymocytes is reversibly arrested in mev/mev mice by a defect in the radiosensitive compartment of the bone marrow microenvironment.


Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C L SidmanR D Allen
Apr 1, 1994·Immunological Reviews·F W Tsui, H W Tsui

Related Concepts

Neoplasm of Uncertain or Unknown Behavior of Thymus
Intravenous Injections
Bone Marrow
Disease of Thymus Gland
Biologic Development
Thyroid Hormone Plasma Membrane Transport Defect
Hematopoiesis, Medullary
Thymic Tissue

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