PMID: 3498788Oct 1, 1987

Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer

The Journal of Experimental Medicine
K L KomschliesIrving Goldschneider

Abstract

Bone marrow prothymocytes from me/me and mev/mev mutant mice fail to generate thymocytes in irradiated (600 rad) +/+ wild-type recipients after intravenous injection. However, these same prothymocytes readily generate thymocytes after intrathymic injection. The results of the present study demonstrate that this apparent defect in the thymus-homing capacity of mev/mev prothymocytes can be corrected by mixing irradiated wild-type bone marrow cells with mev/mev bone marrow cells before intravenous injection. However, this defect is not corrected by passage of mev/mev bone marrow cells through the bone marrow of irradiated wild-type recipients. One interpretation of these results is that the maturation of prothymocytes is reversibly arrested in mev/mev mice by a defect in the radiosensitive compartment of the bone marrow microenvironment.

References

Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C L SidmanR D Allen
Apr 1, 1994·Immunological Reviews·F W Tsui, H W Tsui

Related Concepts

T-Lymphocyte
Neoplasm of Uncertain or Unknown Behavior of Thymus
Intravenous Injections
Bone Marrow
Thymocyte
Disease of Thymus Gland
Biologic Development
Thyroid Hormone Plasma Membrane Transport Defect
Hematopoiesis, Medullary
Thymic Tissue

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