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Defective lysosomal enzyme secretion in kidneys of Chediak-Higashi (beige) mice

The Journal of Cell Biology

Dec 1, 1975

Elisa Fabiana BrandtRichard T Swank

PMID: 408

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Abstract

The beige mouse is an animal model for the human Chediak-Higashi syndrome, a disease characterized by giant lysosomes in most cell types. In mice, treatment with androgenic hormones causes a 20-50-fold elevation in at least one kidney lysosomal enzyme, beta-glucuronidase. Beige mice tre...read more

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    • References19
    • Citations68
    • References19
    • Citations68
  • Defective lysosomal enzyme secretion in kidneys of Chediak-Higashi (beige) mice

    The Journal of Cell Biology

    Dec 1, 1975

    Elisa Fabiana BrandtRichard T Swank

    PMID: 408

    DOI:

    Abstract

    The beige mouse is an animal model for the human Chediak-Higashi syndrome, a disease characterized by giant lysosomes in most cell types. In mice, treatment with androgenic hormones causes a 20-50-fold elevation in at least one kidney lysosomal enzyme, beta-glucuronidase. Beige mice tre...read more

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    References
    • References19
    • Citations68
    • References19
    • Citations68
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