PMID: 641264May 1, 1978Paper

Defective monocyte and polymorphonuclear leukocyte chemotaxis in atopic disease

The Journal of Allergy and Clinical Immunology
C T Furukawa, L C Altman

Abstract

Monocyte (MN) and polymorphonuclear (PMN) leukocyte chemotaxis was studied in 17 atopic children with hyperimmunoglobulinemia E (IgE), 9 age- and diagnosis-matched children with normal IgE levels, 10 pediatric controls, and 45 adult controls. Twenty-one of the 26 atopic patients had eczema, while 5 had only respiratory allergies. All patients were free of infection and receiving no systemic corticosteroids. Depressed PMN chemotaxis was found in only one patient. Defects of MN chemotaxis were detected in 8 of 17 atopic children with IgE and 2 of 9 with normal IgE values. Seven of 21 patients with atopic eczema and 3 of 5 with respiratory allergies had depressed MN chemoatxis. No evidence was found for a cell-directed chemotactic inhibitor in the plasma of patients with abnormal MN chemotaxis. These data demonstrate that: (1) MN chemotaxis is frequently depressed in uninfected atopic patients; (2) this abnormality occurs in patients with respiratory allergies as well as in those with eczema and is more prevalent in atopics with IgE; and (3) PMN chemotactic defects are uncommon in allergic patients. Whether abnormal MN chemotaxis is a primary or a secondary event in atopy requires further investigation.

Citations

Jan 1, 1980·Archives of Dermatological Research·K KragballeJ R Jensen
Jan 1, 1981·Springer Seminars in Immunopathology·P G Quie
Aug 1, 1984·Developmental Biology·K Venkatasubramanian, M Solursh
Jan 1, 1989·Tissue & Cell·S H SmithD S Smith
Feb 1, 1982·Immunopharmacology·T E Van DykeR J Genco
Mar 1, 1983·Veterinary Immunology and Immunopathology·G S Smith, J H Lumsden
Jan 4, 2003·Ophthalmology·Stephen M BoorsteinVictor M Elner
Mar 10, 2000·Immunology Letters·S DunzendorferC J Wiedermann
Jul 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C CariniF Aiuti
Apr 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·O FukutomiT Orii
Jan 1, 1985·Comparative Immunology, Microbiology and Infectious Diseases·P C Wilkinson
Mar 1, 1990·Immunology Today·E J Leonard, T Yoshimura
Jan 1, 1986·Advances in Enzyme Regulation·N KatunumaH Kido
Mar 1, 1983·Journal of the American Academy of Dermatology·J Ring, J Lutz
Oct 12, 2012·Annals of the New York Academy of Sciences·Virgil A S H DalmHemmo A Drexhage
Apr 1, 1980·International Journal of Dermatology·S C Whited, J I Gallin
Dec 1, 1988·The Journal of Allergy and Clinical Immunology·U MrowietzE Christophers
May 1, 1987·The British Journal of Dermatology·F ChiarelliG Morgese
Mar 1, 1988·Acta paediatrica Scandinavica·F ChiarelliG Morgese
Jan 1, 1988·Annals of the New York Academy of Sciences·J L BenachP C Deponte

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Related Papers

The Journal of Allergy and Clinical Immunology
R SnydermanR H Buckley
Archives of Dermatological Research
K KragballeJ R Jensen
International Archives of Allergy and Applied Immunology
D AlthausH Cottier
International Archives of Allergy and Applied Immunology
M Radermecker, M P Maldague
© 2021 Meta ULC. All rights reserved